Sarac Esra, Meiwes Andreas, Eigentler Thomas, Forchhammer Stephan, Kofler Lukas, Häfner Hans-Martin, Garbe Claus
Center for Dermatooncology, Department of Dermatology, Eberhard Karls University, Liebermeisterstraße 25, DE-72076 Tuebingen, Germany.
Acta Derm Venereol. 2020 Nov 23;100(18):adv00328. doi: 10.2340/00015555-3689.
Electrical impedance spectroscopy is a non-invasive technique that can help clinicians in diagnosing malignant skin tumours. Depending on the cellular irregularity of the lesion, electrical impedance spectroscopy can reveal changes in the structure and form of the cells, using a harmless electrical current applied to the skin. A score between 0 and 10 is generated by the electrical impedance spectrometer, where 0 is considered benign and 10 is malignant. This prospective study was conducted in 101 patients with a total of 200 skin lesions; 62 benign and 138 malignant. There was a significant difference between the electrical impedance of malignant and benign lesions (p < 0.001). The sensitivity, specificity, positive predictive value and negative predictive value of electrical impedance spectroscopy for non-melanoma skin cancer were 94.2%, 41.9%, 78.3% and 76.5%, respectively, when the cut-off for the electrical impedance spectroscopy score was set at between 5 and 6. The area under the curve in receiver operating characteristics analyses was 0.758.
电阻抗光谱法是一种非侵入性技术，可帮助临床医生诊断恶性皮肤肿瘤。根据病变的细胞不规则性，电阻抗光谱法可通过向皮肤施加无害电流来揭示细胞结构和形态的变化。电阻抗光谱仪会生成一个介于0到10之间的分数，其中0被认为是良性的，10是恶性的。这项前瞻性研究对101名患者共200处皮肤病变进行了研究；其中62处为良性病变，138处为恶性病变。恶性病变和良性病变的电阻抗之间存在显著差异（p < 0.001）。当电阻抗光谱法分数的临界值设定在5到6之间时，电阻抗光谱法对非黑色素瘤皮肤癌的敏感性、特异性、阳性预测值和阴性预测值分别为94.2%、41.9%、78.3%和76.5%。在受试者工作特征分析中，曲线下面积为0.758。
