Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
NHC Key Laboratory of Myopia, Ministry of Health (Fudan University), and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.
Curr Eye Res. 2021 Jul;46(7):1018-1024. doi: 10.1080/02713683.2020.1849728. Epub 2020 Nov 26.
: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA).: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure suspect, 22 eyes with primary angle closure [PAC], and 25 eyes with primary angle closure glaucoma [PACG]) and 27 control eyes. OCTA was performed for all subjects to acquire a 4.5 × 4.5 mm scanning area centered on the optic discs and a 3 × 3 mm parafoveal cubes. Peripapillary and parafoveal vessel density (VD) were compared between these four groups, and the relationship between VD values and structural and functional changes was evaluated.: Among all four groups, the peripapillary VD of the PACG eyes was the lowest in all six sections (all < .01), while the parafoveal VD was lower than that of the normal group only in the average, superior, and inferior areas (all < .05). The PAC group had lower peripapillary VD than the normal group (62.6[55.2-67.4] vs. 66.7[54.7-69.3], = .01), while their retinal nerve fiber layer (RNFL) and ganglion cell complex thickness were not significantly different than those of the control group (all > .05). In addition, the stages of PACD, visual field mean deviation, and RNFL thickness were shown to be predictors of the peripapillary VD in the multiple linear regression analysis.: The PAC eyes had lower peripapillary VD than normal eyes when their RNFL and GCC thickness did not differ. This suggests that a reduction in retinal VD may occur before structural loss in PAC eyes. Retinal VD measurement may be a useful tool for the assessment of PACD.
: 利用光相干断层扫描血管造影术（OCTA）评估原发性闭角型青光眼（PACD）患者的视盘周围和旁中心区的微血管密度。: 本研究为观察性研究，纳入了 76 例 PACD 患者（29 只眼为原发性闭角型青光眼可疑，22 只眼为原发性闭角型青光眼，25 只眼为原发性闭角型青光眼）和 27 只对照眼。对所有受试者进行 OCTA 检查，以获得以视盘为中心的 4.5×4.5mm 扫描区和 3×3mm 旁黄斑立方体。比较了这四组之间的视盘周围和旁黄斑区血管密度（VD），并评估了 VD 值与结构和功能变化之间的关系。: 在所有四组中，PACG 眼的视盘周围 VD 在所有六个节段均最低（均<0.01），而旁黄斑 VD 仅在平均、上和下区域低于正常组（均<0.05）。PAC 组的视盘周围 VD 低于正常组（62.6[55.2-67.4] 比 66.7[54.7-69.3]，=0.01），而其视网膜神经纤维层（RNFL）和节细胞复合体厚度与对照组无显著差异（均>0.05）。此外，PACD 分期、视野平均偏差和 RNFL 厚度在多元线性回归分析中显示为视盘周围 VD 的预测因素。: 在 PAC 眼的 RNFL 和 GCC 厚度没有差异的情况下，其视盘周围 VD 低于正常眼。这表明在 PAC 眼发生结构丢失之前，视网膜 VD 可能会减少。视网膜 VD 测量可能是评估 PACD 的有用工具。
