Department of Pharmacy Practice, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA.
Breast Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, Sutton, Surrey SM1 2JP, United Kingdom; Breast Cancer Research Division, The Institute of Cancer Research, London SM2 5NG, United Kingdom.
J Geriatr Oncol. 2021 May;12(4):658-665. doi: 10.1016/j.jgo.2020.10.018. Epub 2020 Nov 7.
Most adults with cancer are over 65 years of age, and this cohort is expected to grow exponentially. Older adults have an increased burden of comorbidities and risk of experiencing adverse events on anticancer treatments, including functional decline. Functional impairment is a predictor of increased risk of chemotherapy toxicity and shorter survival in this population. Healthcare professionals caring for older adults with cancer should be familiar with the concept of functional status and its implications because of the significant interplay between function, cancer, anticancer treatments, and patient-reported outcomes. In this narrative review, we provide an overview of functional status among older patients with cancer including predictors, screening, and assessment tools. We also discuss the impact of functional impairment on patient outcomes, and describe the role of individual members of an interprofessional team in addressing functional impairment in this population, including the use of a collaborative approach aiming to preserve function.
大多数患有癌症的成年人年龄在 65 岁以上，预计这一年龄段的人数将呈指数级增长。老年人患有合并症的负担加重，并且在接受抗癌治疗时发生不良事件的风险增加，包括功能下降。在这一人群中，功能障碍是化疗毒性风险增加和生存时间缩短的预测因素。照顾老年癌症患者的医疗保健专业人员应该熟悉功能状态及其影响，因为功能、癌症、抗癌治疗和患者报告的结果之间存在着显著的相互作用。在这篇叙述性综述中，我们概述了老年癌症患者的功能状态，包括预测因素、筛查和评估工具。我们还讨论了功能障碍对患者预后的影响，并描述了跨专业团队中各个成员在解决这一人群功能障碍方面的作用，包括使用旨在维持功能的协作方法。
