Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, USA.
Department of Oncology, Odense University Hospital, Odense, Denmark. Electronic address: https://twitter.com/G_LipositsMD.
ESMO Open. 2024 Aug;9(8):103657. doi: 10.1016/j.esmoop.2024.103657. Epub 2024 Aug 19.
With the aging population, older adults constitute a growing proportion of the new cancer cases. Given the heterogeneous health status among older adults and their susceptibility to aging-related vulnerabilities, understanding their diversity and its implications becomes increasingly crucial for prognostication and guiding diagnostics, treatment decisions, and follow-up, as well as informing supportive care interventions. Geriatric assessment and management (GAM) refers to the comprehensive evaluation of an older individual's health status with subsequent management plans focusing on both oncologic and non-oncologic interventions. In 2019, the European Society for Medical Oncology (ESMO) and the International Society of Geriatric Oncology (SIOG) established the ESMO/SIOG Cancer in the Elderly Working Group. This position paper reflects the recommendations of the working group. Our paper summarizes the existing evidence with a focus on recent key trials and based on this, we propose several recommendations and future directions.
随着人口老龄化，老年人在新发癌症病例中所占比例越来越大。鉴于老年人的健康状况存在异质性，且他们易受到与衰老相关的脆弱性影响，了解他们的多样性及其影响对于预测、指导诊断、治疗决策和随访，以及提供支持性护理干预措施变得越来越重要。老年评估和管理（GAM）是指对老年人健康状况进行全面评估，随后制定管理计划，重点关注肿瘤学和非肿瘤学干预措施。2019 年，欧洲肿瘤内科学会（ESMO）和国际老年肿瘤学会（SIOG）成立了 ESMO/SIOG 老年癌症工作组。本立场文件反映了工作组的建议。我们的论文总结了现有证据，重点关注最近的关键试验，并在此基础上提出了一些建议和未来方向。
