Kendler B S
Department of Biology, Manhattan College, Riverdale, New York 10471.
Prev Med. 1987 Sep;16(5):670-85. doi: 10.1016/0091-7435(87)90050-8.
Garlic and onion have been used for millenia in the traditional medical practice of many cultures to treat cardiovascular and other disorders. Both Allium species, their extracts, and the chemical constituents of these plants have been investigated for possible effects on cardiovascular disease risk factors--both definite (hyperlipidemia, hypertension and hyperglycemia) and suspected (platelet aggregation and blood fibrinolytic activity). Action of these Allium species on blood coagulability is more clearly defined than their effect on the other risk factors. While many of the studies have serious methodological shortcomings, there is some evidence to suggest that use of certain formulations of garlic and/or onion is accompanied by favorable effects on risk factors in normal subjects and in patients with atherosclerotic disease. The possibility of toxicity resulting from acute and chronic ingestion of large amounts of these plants or their extracts is unresolved. Accordingly, further clinical and epidemiological studies are required before the role of these plants in the prevention and control of cardiovascular disorders is understood and can be realized. Additional research in this area is recommended.
数千年来，大蒜和洋葱在许多文化的传统医学实践中被用于治疗心血管疾病和其他疾病。人们对这两种葱属植物、它们的提取物以及这些植物的化学成分进行了研究，以探究其对心血管疾病风险因素的可能影响，这些因素包括确定的（高脂血症、高血压和高血糖）和疑似的（血小板聚集和血液纤溶活性）。与它们对其他风险因素的影响相比，这些葱属植物对血液凝固性的作用更为明确。虽然许多研究存在严重的方法学缺陷，但有证据表明，使用某些大蒜和/或洋葱制剂对正常人和动脉粥样硬化疾病患者的风险因素有积极影响。大量食用这些植物或其提取物导致急性和慢性中毒的可能性尚未明确。因此，在了解并实现这些植物在预防和控制心血管疾病中的作用之前，需要进一步的临床和流行病学研究。建议在该领域进行更多研究。
