大蒜、洋葱与心血管危险因素。对人体实验证据的综述，重点关注市售制剂。
Garlic, onions and cardiovascular risk factors. A review of the evidence from human experiments with emphasis on commercially available preparations.
作者信息
Kleijnen J, Knipschild P, ter Riet G
机构信息
Department of Epidemiology/Health Care Research, University of Limburg, Maastricht, The Netherlands.
出版信息
Br J Clin Pharmacol. 1989 Nov;28(5):535-44. doi: 10.1111/j.1365-2125.1989.tb03539.x.
Abstract
- Claims for beneficial effects on cholesterol levels, fibrinolytic activity, and platelet aggregation are attributed both to fresh garlic and onions (or their extracts) and to commercially available preparations. 2. Regarding fresh garlic, the claims have been confirmed, but so far only at very high dosages. 3. For onions and commercially available supplements contradictory results have been reported. 4. All published trials showed severe methodological shortcomings. Some trials were not randomized and/or not blinded whilst this was possible, and in only one of every three studies more than 25 patients participated in each treatment group. In no trial was prognostic comparability of the treatment and the control groups ascertained. At the moment there is inadequate scientific justification for garlic supplementation.
摘要
- 大蒜和洋葱（或其提取物）以及市售制剂均宣称对胆固醇水平、纤溶活性和血小板聚集有有益作用。2. 关于新鲜大蒜，这些宣称已得到证实，但目前仅在非常高的剂量下得到证实。3. 关于洋葱和市售补充剂，已有相互矛盾的结果报道。4. 所有已发表的试验都存在严重的方法学缺陷。一些试验在可行的情况下未进行随机分组和/或未设盲，而且每三项研究中只有一项研究每个治疗组的参与患者超过25例。没有一项试验确定治疗组和对照组在预后方面的可比性。目前，补充大蒜缺乏充分的科学依据。
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