Division of Vascular & Interventional Radiology, Minimally Invasive Therapeutics Laboratory, Mayo Clinic, 13400 East Shea Blvd., Scottsdale, AZ, 85259, USA.
Division of Anatomic Pathology & Laboratory Medicine, Department of Pathology, Mayo Clinic, 5777 East Mayo Blvd., Phoenix, AZ, 85054, USA.
Adv Mater. 2020 Dec;32(52):e2005603. doi: 10.1002/adma.202005603. Epub 2020 Nov 11.
Vascular embolization is a life-saving minimally invasive catheter-based procedure performed to treat bleeding vessels. Through these catheters, numerous metallic coils are often pushed into the bleeding artery to stop the blood flow. While there are numerous drawbacks to coil embolization, physician expertise, availability of these coils, and their costs further limit their use. Here, a novel blood-derived embolic material (BEM) with regenerative properties, that can achieve instant and durable intra-arterial hemostasis regardless of coagulopathy, is developed. In a large animal model of vascular embolization, it is shown that the BEM can be prepared at the point-of-care within 26 min using fresh blood, it can be easily delivered using clinical catheters to embolize renal and iliac arteries, and it can achieve rapid hemostasis in acutely injured vessels. In swine arteries, the BEM increases cellular proliferation, angiogenesis, and connective tissue deposition, suggesting vessel healing and durable vessel occlusion. The BEM has significant advantages over embolic materials used today, making it a promising new tool for embolization.
血管栓塞是一种挽救生命的微创导管介入治疗方法，用于治疗出血的血管。通过这些导管，通常会将许多金属线圈推入出血的动脉以阻止血流。尽管线圈栓塞有许多缺点，但医生的专业知识、这些线圈的可用性及其成本进一步限制了它们的使用。在这里，开发了一种具有再生特性的新型血液衍生栓塞材料 (BEM)，无论凝血功能如何，它都可以实现即时和持久的动脉内止血。在血管栓塞的大型动物模型中，结果表明，BEM 可以使用新鲜血液在 26 分钟内现场制备，它可以使用临床导管轻松输送以栓塞肾动脉和髂动脉，并且可以快速实现急性损伤血管的止血。在猪的动脉中，BEM 增加了细胞增殖、血管生成和结缔组织沉积，提示血管愈合和持久的血管闭塞。BEM 与当今使用的栓塞材料相比具有显著优势，使其成为栓塞治疗的有前途的新工具。
