1Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay Road, Kowloon, Hong Kong, China
Curr Alzheimer Res. 2020;17(8):687-697. doi: 10.2174/1567205017666201111114928.
Circular RNAs (circRNAs) are a kind of non-coding RNA molecule with highly stable circular structures. CircRNAs are primarily composed of exons and/or introns. Recently, a lot of exciting studies showed that circRNA played an essential role in the development of nervous system diseases. Here, classification, characteristics, biogenesis, and the association of circRNA dysregulation with nervous system diseases, such as Alzheimer's disease, are summarized. The review not only contributes to a better understanding of circRNAs, but also provides new research directions toward the diagnosis, treatment, and prevention of nervous system diseases.
环状 RNA（circRNA）是一种具有高度稳定环状结构的非编码 RNA 分子。circRNA 主要由外显子和/或内含子组成。最近，大量令人兴奋的研究表明，circRNA 在神经系统疾病的发展中起着至关重要的作用。在这里，总结了 circRNA 的分类、特征、生物发生以及与神经系统疾病（如阿尔茨海默病）相关的 circRNA 失调。该综述不仅有助于更好地理解 circRNA，而且为神经系统疾病的诊断、治疗和预防提供了新的研究方向。
