Du Xing, Chen Zhongyao, Shui Wei
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Orthopedic Laboratory of Chongqing Medical University, Chongqing, China.
Front Genet. 2024 May 9;15:1378026. doi: 10.3389/fgene.2024.1378026. eCollection 2024.
Osteoporosis, as a chronic metabolic bone disease, has the characteristic of insidious disease progression, which often leads to relatively delayed disease diagnosis. Therefore, early screening for osteoporosis has become a major public health challenge. The latest research indicates that circRNA is widely involved in the regulation of bone metabolism and is closely related to the occurrence and development of osteoporosis. Based on its high degree of sequence conservation and stability, circRNA has the potential to become a new clinical biomarker. The study of biomarkers is generally based on body fluid samples or adjacent tissue samples, with blood being the most commonly used, which can be divided into sources such as serum, plasma, peripheral blood monocytes, and plasma exosomes. Therefore, this article aims to review the research status of circRNA as a biomarker of osteoporosis.
骨质疏松症作为一种慢性代谢性骨病，具有疾病进展隐匿的特点，这常常导致疾病诊断相对延迟。因此，骨质疏松症的早期筛查已成为一项重大的公共卫生挑战。最新研究表明，环状RNA（circRNA）广泛参与骨代谢的调控，与骨质疏松症的发生发展密切相关。基于其高度的序列保守性和稳定性，circRNA有潜力成为一种新的临床生物标志物。生物标志物的研究一般基于体液样本或邻近组织样本，血液是最常用的，血液样本可分为血清、血浆、外周血单核细胞和血浆外泌体等来源。因此，本文旨在综述circRNA作为骨质疏松症生物标志物的研究现状。
