Hadfield T L, Smith M B, Winn R E, Rinaldi M G, Guerra C
Department of Pathology, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas 78236-5300.
Rev Infect Dis. 1987 Sep-Oct;9(5):1006-12. doi: 10.1093/clinids/9.5.1006.
Candida lusitaniae, a fungus with a low incidence of infection in immunocompetent people, is emerging as an opportunistic pathogen in immunocompromised hosts. This yeast is generally resistant to amphotericin B and may present therapeutic difficulties. C. lusitaniae may be misidentified as one of several other fungal species, including Candida tropicalis, Candida parapsilosis, and even Saccharomyces cerevisiae. As judged by in vitro antifungal susceptibility testing, minimal inhibitory concentrations of antifungal agents other than amphotericin B are achievable, but fungicidal levels are not. When encountered in blood or other body sites, C. lusitaniae should be carefully considered as a potential pathogen.
葡萄牙念珠菌是一种在免疫功能正常人群中感染发生率较低的真菌,正逐渐成为免疫功能低下宿主中的机会性病原体。这种酵母菌通常对两性霉素B耐药,可能会带来治疗难题。葡萄牙念珠菌可能会被误鉴定为其他几种真菌之一,包括热带念珠菌、近平滑念珠菌,甚至酿酒酵母。根据体外抗真菌药敏试验判断,除两性霉素B外的抗真菌药物可达到最低抑菌浓度,但达不到杀菌水平。当在血液或其他身体部位发现葡萄牙念珠菌时,应谨慎将其视为潜在病原体。