Li Chenyu, Chen Sizhe, Wang Yun, Su Qi
Microbiota I-Center (MagIC), Hong Kong SAR, China.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Int J Mol Sci. 2024 Dec 9;25(23):13208. doi: 10.3390/ijms252313208.
Insomnia poses considerable risks to both physical and mental health, leading to cognitive impairment, weakened immune function, metabolic dysfunction, cardiovascular issues, and reduced quality of life. Given the significant global increase in insomnia and the growing scientific evidence connecting gut microbiota to this disorder, targeting gut microbiota as an intervention for insomnia has gained popularity. In this review, we summarize current microbiome-based therapeutics for insomnia, including dietary modifications; probiotic, prebiotic, postbiotic, and synbiotic interventions; and fecal microbiota transplantation. Moreover, we assess the capabilities and weaknesses of these technologies to offer valuable insights for future studies.
失眠对身心健康构成了相当大的风险，会导致认知障碍、免疫功能减弱、代谢功能紊乱、心血管问题以及生活质量下降。鉴于全球失眠症显著增加，且越来越多的科学证据将肠道微生物群与这种疾病联系起来，将肠道微生物群作为失眠症的一种干预手段已受到广泛关注。在这篇综述中，我们总结了目前基于微生物群的失眠症治疗方法，包括饮食调整；益生菌、益生元、后生元及合生元干预；以及粪便微生物群移植。此外，我们评估了这些技术的优缺点，为未来的研究提供有价值的见解。
