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药用植物成分槲皮素对石斑鱼虹彩病毒感染的抑制活性及抗病毒机制

The Inhibitory Activities and Antiviral Mechanism of Medicinal Plant Ingredient Quercetin Against Grouper Iridovirus Infection.

作者信息

Liu Mingzhu, Yu Qing, Xiao Hehe, Li Mengmeng, Huang Yaming, Zhang Qin, Li Pengfei

机构信息

Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Beibu Gulf Marine Industrial Research Institute, Guangxi Academy of Sciences, Nanning, China.

College of Life Science, Henan Normal University, Xinxiang, China.

出版信息

Front Microbiol. 2020 Oct 16;11:586331. doi: 10.3389/fmicb.2020.586331. eCollection 2020.

DOI:10.3389/fmicb.2020.586331
PMID:33178170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7596301/
Abstract

Singapore grouper iridovirus (SGIV) causes high mortality rates in mariculture, and effective treatments against SGIV infection are urgently required. Hook. f. () is a well-known medicinal plant with a variety of biological activities. The natural ingredient quercetin isolated from could effectively inhibit SGIV infection in a dose-dependent manner. The possible antiviral mechanism of quercetin was further analyzed in this study. It showed that quercetin did obvious damages to SGIV particles. Furthermore, quercetin could interfere with SGIV binding to targets on host cells (by 76.14%), disturb SGIV invading into host cells (by 56.03%), and effect SGIV replication in host cells (by 52.73%), respectively. Quercetin had the best antiviral effects during the SGIV life cycle of binding to the receptors on host cells' membranes. Overall, the results suggest that quercetin has direct and host-mediated antiviral effects against SGIV and holds great potential for developing effective drugs to control SGIV infection in aquaculture.

摘要

新加坡石斑鱼虹彩病毒（SGIV）在海水养殖中导致高死亡率，因此迫切需要针对SGIV感染的有效治疗方法。 钩吻（Hook. f.）是一种具有多种生物活性的著名药用植物。 从钩吻中分离出的天然成分槲皮素可以剂量依赖性方式有效抑制SGIV感染。 本研究进一步分析了槲皮素可能的抗病毒机制。 结果表明，槲皮素对SGIV颗粒有明显损伤。 此外，槲皮素可分别干扰SGIV与宿主细胞上靶标的结合（降低76.14%）、干扰SGIV侵入宿主细胞（降低56.03%）以及影响SGIV在宿主细胞中的复制（降低52.73%）。 在SGIV与宿主细胞膜上受体结合的生命周期阶段，槲皮素具有最佳抗病毒效果。 总体而言，结果表明槲皮素对SGIV具有直接和宿主介导的抗病毒作用，在开发控制水产养殖中SGIV感染的有效药物方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/540e13ac0fcf/fmicb-11-586331-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/74d4e7301a33/fmicb-11-586331-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/c07bb4a076af/fmicb-11-586331-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/540e13ac0fcf/fmicb-11-586331-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/05ee80b3b3e3/fmicb-11-586331-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/e90949525b72/fmicb-11-586331-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/1d5aa0227537/fmicb-11-586331-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/0cdb16cd434b/fmicb-11-586331-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/74d4e7301a33/fmicb-11-586331-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/c07bb4a076af/fmicb-11-586331-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c8f/7596301/540e13ac0fcf/fmicb-11-586331-g007.jpg

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