Alonazi Mona, Horchani Habib, Alwhibi Mona, Ben Bacha Abir
Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia.
Science Department, College of Rivière-Du-Loup, Rivière-Du-Loup, Québec, Canada G5R1E2.
Oxid Med Cell Longev. 2020 Oct 29;2020:9835167. doi: 10.1155/2020/9835167. eCollection 2020.
Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipase, phospholipase, protease, -amylase, -glucosidase, and xanthine oxidase activities under treatment with aqueous and ethanolic extracts of were observed to evaluate the inhibitory effect of these extracts, as well as their antioxidant and cytotoxic effects. Results showed that ethanolic and aqueous extracts exhibited important inhibitory activity in a concentration-related manner on digestive enzymes, which is more effective than the commercial drugs used as controls. Results also showed that, out of the two extracts tested, the ethanolic extract presented the most promising results in inhibiting the activities of all digestive enzymes used. Moreover, the two extracts displayed a higher reducing power than that of the positive control used. The obtained results, together with previous reports in the literature, strongly suggest that extracts may be natural inhibitors of the digestive enzymes and thus a potential new drug for metabolic syndrome treatment.
大戟属植物具有广泛的治疗应用。本研究旨在通过抑制脂质和碳水化合物吸收来研究来自[具体植物名称未给出]的新型抗消化酶剂，以评估其在治疗代谢综合征方面的潜在应用。观察了[具体植物名称未给出]水提取物和乙醇提取物处理下的脂肪酶、磷脂酶、蛋白酶、α-淀粉酶、α-葡萄糖苷酶和黄嘌呤氧化酶活性，以评估这些提取物的抑制作用以及它们的抗氧化和细胞毒性作用。结果表明，乙醇提取物和水提取物对消化酶表现出重要的浓度相关抑制活性，比用作对照的商业药物更有效。结果还表明，在所测试的两种提取物中，乙醇提取物在抑制所有所用消化酶的活性方面呈现出最有前景的结果。此外，这两种提取物显示出比所用阳性对照更高的还原能力。所获得的结果与文献中的先前报道一起，强烈表明[具体植物名称未给出]提取物可能是消化酶的天然抑制剂，因此是治疗代谢综合征的潜在新药。
