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Exp Ther Med. 2020 Mar;19(3):1940-1946. doi: 10.3892/etm.2019.8402. Epub 2019 Dec 31.
2
Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke.人尿激肽原酶或依达拉奉联合丁苯酞治疗急性缺血性脑卒中。
Brain Behav. 2019 Dec;9(12):e01438. doi: 10.1002/brb3.1438. Epub 2019 Oct 22.
3
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Chin Med J (Engl). 2019 Jun 20;132(12):1467-1477. doi: 10.1097/CM9.0000000000000289.
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Vascular cognitive impairment: Advances and trends.血管性认知障碍：进展与趋势。
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6
Pharmacotherapy for Vascular Cognitive Impairment.血管性认知障碍的药物治疗。
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Clin Sci (Lond). 2017 Jun 1;131(11):1059-1068. doi: 10.1042/CS20160607.
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10
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丁苯酞作为血管性痴呆辅助治疗的疗效与安全性：一项系统评价与Meta分析方案

Efficacy and safety of butylphthalide as adjunctive therapy for vascular dementia: A protocol for systematic review and meta-analysis.

作者信息

Zhou Ling, Yang Rong, Wu Feiyue

机构信息

Zhoushan Hospital, Zhejiang University School of Medicine, Zhejiang, China.

出版信息

Medicine (Baltimore). 2020 Nov 13;99(46):e23236. doi: 10.1097/MD.0000000000023236.

DOI:10.1097/MD.0000000000023236
PMID:33181711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7668513/
Abstract

BACKGROUND

Butylphthalide is widely used for the adjunctive treatment of vascular dementia; however, the clinical evidences are not well synthesized yet.

METHODS

We proposed a systematic review and meta-analysis to evaluate the efficacy and safety of butylphthalide as adjunctive therapy for vascular dementia. Seven electronic databases (China National Knowledge Infrastructure, Wanfang database, Chongqing VIP database, China Biomedical Literature Database, Pubmed, EMBASE and Cochrane library) will be searched for eligible randomized controlled trials (RCTs). Required data of included studies will be collected. Quality of studies will be evaluated using Cochrane risk of bias assessment tool. Data synthesis will be performed using Review Manager software. Subgroup analysis and sensitivity analysis will also be carried.

RESULTS

Synthesis results of current available RCTs regarding the efficacy and safety of butylphthalide for the treatment vascular dementia will be provided by this systematic review and meta-analysis.

CONCLUSION

This systematic review and meta-analysis will provide high level evidence of butylphthalide clinical application.

REGISTRATION

PROSPERO CRD42020168947.

摘要

背景

丁苯酞广泛用于血管性痴呆的辅助治疗；然而，临床证据尚未得到充分整合。

方法

我们开展了一项系统评价和荟萃分析，以评估丁苯酞作为血管性痴呆辅助治疗的疗效和安全性。将检索七个电子数据库（中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、EMBASE和Cochrane图书馆），查找符合条件的随机对照试验（RCT）。将收集纳入研究所需的数据。将使用Cochrane偏倚风险评估工具评估研究质量。将使用Review Manager软件进行数据合成。还将进行亚组分析和敏感性分析。

结果

本系统评价和荟萃分析将提供关于丁苯酞治疗血管性痴呆疗效和安全性的现有RCT的综合结果。

结论

本系统评价和荟萃分析将为丁苯酞的临床应用提供高水平证据。

注册信息

PROSPERO CRD42020168947