Department of Technology of Pharmacutical Formulations, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov, 14a, Saint-Petersburg 197376, Russia.
Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), Vladimirskaya, 17, Murmansk 183010, Russia.
Mar Drugs. 2020 Nov 9;18(11):557. doi: 10.3390/md18110557.
Marine organisms represent an excellent source of innovative compounds that have the potential for the development of new drugs. The pharmacokinetics of marine drugs has attracted increasing interest in recent decades due to its effective and potential contribution to the selection of rational dosage recommendations and the optimal use of the therapeutic arsenal. In general, pharmacokinetics studies how drugs change after administration via the processes of absorption, distribution, metabolism, and excretion (ADME). This review provides a summary of the pharmacokinetics studies of marine-derived active compounds, with a particular focus on their ADME. The pharmacokinetics of compounds derived from algae, crustaceans, sea cucumber, fungus, sea urchins, sponges, mollusks, tunicate, and bryozoan is discussed, and the pharmacokinetics data in human experiments are analyzed. In-depth characterization using pharmacokinetics is useful for obtaining information for understanding the molecular basis of pharmacological activity, for correct doses and treatment schemes selection, and for more effective drug application. Thus, an increase in pharmacokinetic research on marine-derived compounds is expected in the near future.
海洋生物是创新化合物的重要来源，这些化合物具有开发新药的潜力。近年来，海洋药物的药代动力学因其对合理剂量建议的选择和治疗武器的最佳利用的有效和潜在贡献而引起了越来越多的关注。一般来说，药代动力学研究药物在通过吸收、分布、代谢和排泄（ADME）过程给药后如何变化。本文综述了海洋来源活性化合物的药代动力学研究，特别关注其 ADME。讨论了来自藻类、甲壳类动物、海参、真菌、海胆、海绵、软体动物、被囊动物和苔藓动物的化合物的药代动力学，并分析了人类实验中的药代动力学数据。使用药代动力学进行深入表征有助于获得理解药理活性的分子基础的信息，有助于正确选择剂量和治疗方案，并有助于更有效地应用药物。因此，预计在不久的将来，对海洋衍生化合物的药代动力学研究将会增加。
