Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing, 210008, China.
J Transl Med. 2020 Nov 12;18(1):432. doi: 10.1186/s12967-020-02609-0.
Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to the physiological status of the secreting cells, EVs are regarded as novel diagnostic and prognostic biomarkers for many diseases. The ability to protect encapsulated molecules from degradation in body fluids suggests the potential of EVs as biological medicines or drug delivery systems. This article focuses on the EV-associated biomarkers and therapeutic approaches in autoimmune diseases.
细胞外囊泡是自然分泌的小囊泡的异质群体。EV 作为信号平台发挥作用，促进细胞内通讯，从而反映细胞或组织的生理或病理生理状况。鉴于 EV 可以从大多数体液中分离出来，并且其分子成分可以根据分泌细胞的生理状态进行重新编程，因此 EV 被认为是许多疾病的新型诊断和预后生物标志物。EV 能够保护囊封分子免受体液降解的能力表明其具有作为生物药物或药物递送系统的潜力。本文重点介绍自身免疫性疾病中与 EV 相关的生物标志物和治疗方法。
