Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
J Leukoc Biol. 2020 Nov;108(5):1565-1573. doi: 10.1002/JLB.3MR0420-067R. Epub 2020 Jun 1.
Extracellular vesicles (EVs) are nanosized particles that have emerged as mediators for intercellular communication in physiologic and pathologic conditions. EVs carry signaling information on their bilipid membrane as well as cargo within, allowing them to perform a wide range of biologic processes and contribute to pathophysiologic roles in a wide range of diseases, including cancer, autoimmune diseases and coagulopathy. This review will specifically address the function of surface molecules on EVs under normal and diseased conditions, as well as their potential to emerge as therapeutic targets in clinical settings, and the importance of further research on the surface topography of EVs.
细胞外囊泡（EVs）是纳米级颗粒，它们在生理和病理条件下作为细胞间通讯的介质而出现。EVs 在其双层膜上携带信号信息以及内部货物，使它们能够执行广泛的生物学过程，并在包括癌症、自身免疫性疾病和凝血障碍在内的广泛疾病中发挥病理生理作用。本综述将特别讨论 EVs 在正常和患病条件下表面分子的功能，以及它们在临床环境中作为治疗靶点的潜力，以及进一步研究 EVs 表面形貌的重要性。
