Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran.
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Clin Nutr ESPEN. 2020 Dec;40:27-33. doi: 10.1016/j.clnesp.2020.09.017. Epub 2020 Oct 16.
This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome (MetS) and related disorders.
Databases including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central library were searched until January 31, 2019.
14 effect sizes from 12 studies were identified eligible to be included in current meta-analysis. Flaxseed supplementation resulted in a significant reduction in interleukin 6 (IL-6) (WMD: -0.22; 95% CI: -0.43, -0.01) and malondialdehyde (MDA) (WMD: -0.17; 95% CI: -0.31, -0.03) and a significant increase in total antioxidant capacity (TAC) levels (WMD: 137.25; 95% CI: 68.04, 206.47). Flaxseed oil supplementation did not affect other biomarkers of inflammation and oxidative stress.
Overall, this meta-analysis demonstrated flaxseed oil supplementation decreased IL-6 and MDA levels, and increased TAC, but did not affect other biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. This suggests that flaxseed oil supplementation may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders.
本系统评价和荟萃分析对随机对照试验（RCT）进行了分析，以研究亚麻籽油补充剂对代谢综合征（MetS）和相关疾病患者炎症和氧化应激生物标志物的影响。
检索了 PubMed、Scopus、EMBASE、Web of Science 和 Cochrane 中央图书馆等数据库，检索时间截至 2019 年 1 月 31 日。
从 12 项研究中确定了 14 个符合条件的效应量，纳入了本次荟萃分析。亚麻籽补充剂可显著降低白细胞介素 6（IL-6）（WMD：-0.22；95%CI：-0.43，-0.01）和丙二醛（MDA）（WMD：-0.17；95%CI：-0.31，-0.03）水平，显著增加总抗氧化能力（TAC）水平（WMD：137.25；95%CI：68.04，206.47）。亚麻籽油补充剂对其他炎症和氧化应激生物标志物没有影响。
总体而言，本荟萃分析表明，亚麻籽油补充剂可降低 IL-6 和 MDA 水平，增加 TAC，但对 MetS 和相关疾病患者的其他炎症和氧化应激生物标志物没有影响。这表明，亚麻籽油补充剂可能在代谢紊乱相关疾病的临床症状改善中发挥了间接作用。
