Department of Polymer Engineering and Color Technology, Amirkabir University of Technology Tehran, Iran; Laboratory of Regenerative Medicine and Biomedical Innovations, Pasteur Institute of Iran, Tehran, Iran.
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology Tehran, Iran.
Carbohydr Polym. 2021 Jan 15;252:117219. doi: 10.1016/j.carbpol.2020.117219. Epub 2020 Oct 15.
In this research, two groups of polyurethane (PU) nanocomposites were developed based on PCL-PEG-PCL tri-block polyols and cellulose nanowhisker (CNW), as a cross-linker and controller of microphase separation of blocks. The effect of PEG block length on phase segregation and crystallization of blocks was evaluated. The impact of tuned crystallization and hard domain morphology on shape memory parameters was studied in detail. PU2000-0.25 % was selected as the optimum specimen with shape fixity and recovery of 100 %. CNW nanorods were found to act as a controlling agent of the microphase segregation, possibly through changing the spatial organization of hard segments from a 3D self-assembled to a shell-like structure. Three different cell lines (HepG2, HFF, and mesenchymal stem cells) were used to culture on the prepared 2D specimens, resulting in different behaviors. The newly synthesized biomaterials with different cellular responses presented a great potential for a variety of tissue engineering applications.
在这项研究中，基于 PCL-PEG-PCL 三嵌段多元醇和纤维素纳米纤维（CNW），开发了两组聚氨酯（PU）纳米复合材料，作为交联剂和控制微相分离的块。评估了 PEG 嵌段长度对相分离和嵌段结晶的影响。详细研究了调谐结晶和硬段形态对形状记忆参数的影响。选择 PU2000-0.25 %作为最佳样品，形状固定率和恢复率为 100 %。发现 CNW 纳米棒作为微相分离的控制剂，可能通过改变硬段的空间组织从 3D 自组装到壳状结构。将三种不同的细胞系（HepG2、HFF 和间充质干细胞）用于在制备的 2D 样品上培养，导致不同的行为。具有不同细胞反应的新型合成生物材料为各种组织工程应用提供了巨大的潜力。
