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尼日利亚中北部成年居民维生素 D 水平低下及其相关因素。

Low Vitamin D Levels and Correlates Amongst Adult Nigerians in North Central Nigeria.

机构信息

Department of Internal Medicine, Asokoro District Hospital, Abuja Nigeria/Department of Internal Medicine, Nile University of Nigeria, Abuja Nigeria.

Department of Surgery, Asokoro District Hospital, Abuja Nigeria/Department of Surgery, Nile University of Nigeria, Abuja Nigeria.

出版信息

West Afr J Med. 2020 Nov;37(6):631-639.

Abstract

BACKGROUND

BACKGROUND: Vitamin D is an essential nutrient which plays vital roles in bone metabolism and in the pathogenesis of both communicable and non-communicable diseases. Global estimates show a high and rising prevalence of low vitamin D levels in different populations, including Africa's. There is paucity of data on vitamin D status in Nigerian adult sub-populations.

AIMS

This study is an attempt at providing insight in to how common low vitamin D is in a Nigerian population and possible associated risk factors.

METHODS

One hundred and five persons, who met the inclusion criteria, had their vitamin D levels estimated alongside their blood pressure and anthropometric checks. Blood glucose, glycated haemoglobin and lipids were estimated. Ordinal logistic regression analyses were performed to determine the association of low vitamin D with certain variables. A p-value of < 0.05 was set as significant.

RESULTS

Fifty-seven males, (54.3%), and forty-eight females (45.7%) were studied. The mean/SD and median ages were 48.8+8.3 years and 50 years respectively. Low Vitamin D levels were observed in fifty subjects (47.6%), mostly in the upper class, and people with dys-metabolism and poor exposure to sunlight.

CONCLUSIONS

Low Vitamin D, mainly insufficiency, is surprisingly common amongst Nigerians, more in the upper socio-economic class. There is correlation between low Vitamin D and poor exposure to sunlight, promoted by affluence, as well as some dysmetabolic states such as type 2 diabetes mellitus, and dyslipidaemia. Adequate exposure to sunlight and vitamin D replacement are recommended.

摘要

背景

维生素 D 是一种必需营养素,在骨骼代谢和传染性及非传染性疾病的发病机制中起着至关重要的作用。全球估计显示,不同人群,包括非洲人群,维生素 D 水平低的发病率很高且呈上升趋势。关于尼日利亚成年亚人群的维生素 D 状况的数据很少。

目的

本研究旨在了解尼日利亚人群中常见的维生素 D 缺乏情况以及可能的相关危险因素。

方法

符合纳入标准的 105 人,评估了他们的维生素 D 水平,同时检查了他们的血压和人体测量。测量了血糖、糖化血红蛋白和血脂。进行了有序逻辑回归分析,以确定维生素 D 水平低与某些变量之间的关联。p 值<0.05 被认为具有统计学意义。

结果

研究了 57 名男性(54.3%)和 48 名女性(45.7%)。平均/标准差和中位数年龄分别为 48.8+8.3 岁和 50 岁。50 名受试者(47.6%)存在维生素 D 水平低,主要见于上层阶级、代谢紊乱和阳光暴露不足的人群。

结论

低维生素 D,主要是不足,在尼日利亚人中出人意料地常见,在上层社会经济阶层中更为常见。维生素 D 缺乏与阳光暴露不足有关,这是由富裕所促进的,以及一些代谢紊乱状态,如 2 型糖尿病和血脂异常。建议进行充足的阳光暴露和维生素 D 补充。

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