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[全球麻疹危机——从武装冲突到疫苗接种怀疑论的多种成因]

[The global measles crisis-a diversity of causes from armed conflicts to vaccination skepticism].

作者信息

Denkel Luisa, Espelage Werner, Matysiak-Klose Dorothea, Morwinsky Thomas, Siedler Anette, Beermann Sandra

机构信息

Abteilung für Infektionsepidemiologie, FG33 - Fachgebiet für Impfprävention, Robert Koch-Institut, Seestraße 10, 10315, Berlin, Deutschland.

Zentrum für internationalen Gesundheitsschutz, ZIG1 - Informationsstelle für Internationalen Gesundheitsschutz, Robert Koch-Institut, Berlin, Deutschland.

出版信息

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 Dec;63(12):1445-1453. doi: 10.1007/s00103-020-03241-5. Epub 2020 Nov 13.

Abstract

BACKGROUND AND AIM

Despite a safe and effective vaccine being available for many years, the number of measles cases has been increasing again worldwide since 2018. Our report aims to identify putative reasons for this development.

METHODS

We conducted a selective literature search. Further, current reports and data from the World Health Organization (WHO), the United Nations Children's Fund (UNICEF), and the World Bank were evaluated.

RESULTS

According to the WHO, Madagascar, the Ukraine, and Israel had the highest incidences of measles worldwide between 1 July 2018 and 30 June 2019. Measles outbreaks are a sign of inadequate vaccination rates caused by multiple structural and psychological barriers. Structural barriers to measles vaccination, such as a lack of routine vaccination programs, have been identified as the main cause of low measles vaccination rates, particularly in fragile countries e.g. due to armed conflicts, but also in some subpopulations of higher-income countries e.g. due to lacking resources for vaccination services. Psychological barriers leading to vaccination skepticism were prevalent mainly in developed countries with well-functioning health systems and a high standard of living.

CONCLUSION

The reasons for the global measles crisis are manifold and in some cases have existed for decades. However, the consequences appear to be accumulating and have had a dramatic impact on case numbers since 2018. The goal of measles elimination and maintenance of the necessary vaccination programs is a constant challenge that requires strict and permanent compliance with WHO recommendations. The number of measles cases reported in Germany is still at a level above the key target for measles elimination specified in the national immunization plan. Timely and/or locally restricted as well as nationwide outbreaks continue to occur. Since infectious agents can be transmitted across borders, the international perspective is an essential component of national health policy in Germany.

摘要

背景与目的

尽管多年来已有安全有效的疫苗,但自2018年以来,全球麻疹病例数再次上升。本报告旨在找出这一发展趋势的可能原因。

方法

我们进行了选择性文献检索。此外,还评估了世界卫生组织(WHO)、联合国儿童基金会(UNICEF)和世界银行的当前报告及数据。

结果

根据WHO的数据,2018年7月1日至2019年6月30日期间,马达加斯加、乌克兰和以色列的麻疹发病率在全球最高。麻疹疫情是由多种结构和心理障碍导致疫苗接种率不足的一个迹象。麻疹疫苗接种的结构障碍,如缺乏常规疫苗接种计划,已被确定为麻疹疫苗接种率低的主要原因,特别是在脆弱国家,如因武装冲突,也在一些高收入国家的亚人群中,如因缺乏疫苗接种服务资源。导致疫苗接种怀疑论的心理障碍主要在卫生系统运作良好且生活水平高的发达国家普遍存在。

结论

全球麻疹危机的原因是多方面的,在某些情况下已经存在了几十年。然而,其后果似乎正在累积,自2018年以来对病例数产生了巨大影响。消除麻疹的目标和维持必要的疫苗接种计划是一项持续的挑战,需要严格和永久遵守WHO的建议。德国报告的麻疹病例数仍高于国家免疫计划中规定的消除麻疹关键目标水平。仍不时发生局部或全国性的疫情爆发。由于传染源可跨境传播,国际视角是德国国家卫生政策的重要组成部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d915/7686185/53cf190737c5/103_2020_3241_Fig1_HTML.jpg

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