School of Dentistry and Oral Health and Menzies Health Institute Queensland, Griffith University Queensland, Gold Coast campus Parklands Drive, Southport, QLD, 4222, Australia.
Department of Prosthodontics, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Odontology. 2021 Apr;109(2):540-546. doi: 10.1007/s10266-020-00570-4. Epub 2020 Nov 13.
This study evaluated the impact of peri-implant treatment in the salivary levels of Colony stimulator factor -1 (CSF-1), S100A8/A9 and S100A12 in patients having mucositis or peri-implantitis. As a secondary aim, we analysed the correlation between the salivary and peri-implant crevicular fluid (PICF) levels. Forty-seven patient, 27 having mucositis (mean age 63.11 ± 7.78) and 20 having peri-implantitis (61.25 ± 7.01) participated in the study. Clinical parameters, probing pocket depth, clinical attachment level, % of plaque and bleeding on probing were evaluated. Unstimulated whole saliva was collected from all patients, while PICF was collected only from a patient's subgroup (n = 20). Samples were collected before and 3 months after peri-implant treatment. Enzyme-linked immunosorbent assays determined levels of CSF-1, S100A8/A9 and S100A12. Clinical parameters improved and salivary levels of CSF-1 and S100A8/A9, but not S100A12, reduced significantly after treatment in both groups. No significant correlation was found in the salivary and PICF levels of the same molecule. In conclusion, the treatment of peri-implant disease significantly improved the clinical parameters and reduced the salivary levels of CSF-1 and S100A8/A9. The salivary expressions of CSF-1, S100A8/A9 and S100A12 did not correlate with their own expression in PICF.
本研究评估了在患有黏膜炎或种植体周围炎的患者中，进行种植体周治疗对集落刺激因子-1（CSF-1）、S100A8/A9 和 S100A12 唾液水平的影响。作为次要目标，我们分析了唾液和种植体周龈沟液（PICF）水平之间的相关性。47 名患者，27 名患有黏膜炎（平均年龄 63.11 ± 7.78）和 20 名患有种植体周围炎（61.25 ± 7.01）参加了研究。评估了临床参数、探诊深度、临床附着水平、菌斑百分比和探诊出血。从所有患者中采集未刺激的全唾液，而仅从患者亚组（n=20）中采集 PICF。在种植体周治疗前和 3 个月采集样本。酶联免疫吸附测定法测定 CSF-1、S100A8/A9 和 S100A12 的水平。在两组中，治疗后临床参数均得到改善，CSF-1 和 S100A8/A9 的唾液水平显著降低，但 S100A12 则没有。在同一分子的唾液和 PICF 水平之间未发现显著相关性。结论：种植体周疾病的治疗显著改善了临床参数，并降低了 CSF-1 和 S100A8/A9 的唾液水平。CSF-1、S100A8/A9 和 S100A12 的唾液表达与它们在 PICF 中的自身表达没有相关性。
