种植体周手术治疗下调种植体周围炎患者 sTREM-1 和 MMP-8 的表达：一项前瞻性研究。

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study.

机构信息

Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil.

Department of Endodontics, School of Dentistry, University of Texas, Houston, TX 77054, USA.

出版信息

Int J Environ Res Public Health. 2022 Mar 18;19(6):3627. doi: 10.3390/ijerph19063627.

DOI:10.3390/ijerph19063627

PMID:35329310

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8955840/

Abstract

sTREM-1 and its ligand PGLYRP1 play an essential role in the inflammatory process around teeth and implants. In this study, we aimed to evaluate the impact of peri-implant treatment on the salivary levels of the sTREM-1/PGLYRP-1/MMP-8 axis after 3 months. A total of 42 participants (with a mean age of 61 years old ± 7.3) were enrolled in this longitudinal study, 24 having peri-implant mucositis (MU) and 18 having peri-implantitis (PI). Clinical peri-implant parameters, such as probing pocket depth (PPD), % of plaque, and bleeding on probing (BOP), and the whole unstimulated saliva samples were evaluated at baseline and 3 months after treatment. The MU group received nonsurgical peri-implant treatment, while the PI group received open-flap procedures. The levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 were analyzed using enzyme-linked immunosorbent assays. BOP, plaque levels, and PPD significantly reduced after treatment in both groups. A significant decrease in the salivary levels of sTREM-1, MMP-8, and TIMP-1 in the PI group and PGLYRP1 and TIMP-1 in the MU group were observed. Salivary levels of sTREM-1 were significantly reduced in patients with PI but not with MU. Additionally, peri-implant treatment had a significantly higher impact on MMP-8 reduction in patients with PI than in those with MU.

摘要

sTREM-1 及其配体 PGLYRP1 在牙齿和种植体周围的炎症过程中发挥着重要作用。在这项研究中，我们旨在评估种植体周围治疗对 3 个月后唾液中 sTREM-1/PGLYRP-1/MMP-8 轴水平的影响。共有 42 名参与者（平均年龄为 61 岁±7.3 岁）参与了这项纵向研究，其中 24 名患有种植体周围黏膜炎（MU），18 名患有种植体周围炎（PI）。在基线和治疗后 3 个月评估了临床种植体周围参数，如探诊袋深度（PPD）、菌斑百分比和探诊出血（BOP），以及全唾液样本。MU 组接受了非手术种植体周围治疗，而 PI 组接受了翻瓣手术。使用酶联免疫吸附试验分析了 sTREM-1、PGLYRP1、MMP-8 和 TIMP-1 的水平。两组治疗后 BOP、菌斑水平和 PPD 均显著降低。PI 组 sTREM-1、MMP-8 和 TIMP-1 以及 MU 组 PGLYRP1 和 TIMP-1 的唾液水平均显著下降。PI 患者的唾液 sTREM-1 水平显著降低，但 MU 患者的唾液 sTREM-1 水平没有降低。此外，与 MU 患者相比，PI 患者的 MMP-8 降低对种植体周围治疗的影响更大。