锌缺乏促进肿瘤发生的潜在途径。
Potential pathways of zinc deficiency-promoted tumorigenesis.
机构信息
Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, 330006, PR China; Queen Mary School, Medical Department, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
出版信息
Biomed Pharmacother. 2021 Jan;133:110983. doi: 10.1016/j.biopha.2020.110983. Epub 2020 Nov 12.
Zinc (Zn) is the second most abundant necessary trace element in the human body. It is reported that zinc deficiency (ZD) promotes many types of cancer progression through multiple signal pathways. It is well known that oxidative stress, DNA damage, DNA repair, cell cycle, cell apoptosis, metabolic alterations, microRNAs abnormal expression, and inflammation level are closely related to cancer development. Cumulative evidence suggests that ZD influences these biological functions. This review explores the latest advances in understanding the role of ZD in tumorigenesis. Fully comprehending the potential mechanisms of ZD-induced tumors may provide novel clues for prevention and clinical treatment of cancers.
锌（Zn）是人体中第二丰富的必需微量元素。据报道，锌缺乏症（ZD）通过多种信号通路促进多种类型的癌症进展。众所周知，氧化应激、DNA 损伤、DNA 修复、细胞周期、细胞凋亡、代谢改变、miRNA 异常表达和炎症水平与癌症的发生密切相关。累积的证据表明，ZD 影响这些生物学功能。本综述探讨了关于 ZD 在肿瘤发生中的作用的最新进展。充分理解 ZD 诱导肿瘤的潜在机制可能为癌症的预防和临床治疗提供新的线索。
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