Department of Immunology, Institute for Advanced Medicine, Wakayama Medical University, Wakayama, Japan.
Laboratory of Immunology, Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan.
Front Immunol. 2022 May 27;13:857954. doi: 10.3389/fimmu.2022.857954. eCollection 2022.
Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions. One DC subset, conventional type 1 DC (cDC1), can be defined by expression of CD8α/CD103 in mice and CD141 in humans, or by expression of a chemokine receptor, XCR1, which is a conserved marker in both mice and human. cDC1 are characterized by high ability to ingest dying cells and to cross-present antigens for generating cytotoxic CD8 T cell responses. Through these activities, cDC1 play crucial roles in immune responses against infectious pathogens or tumors. Meanwhile, cDC1 involvement in homeostatic situations is not fully understood. Analyses by using mutant mice, in which cDC1 are ablated , revealed that cDC1 are critical for maintaining intestinal immune homeostasis. Here, we review the homeostatic roles of cDC1, focusing upon intestinal immunity.
树突状细胞 (DC) 在连接先天免疫和适应性免疫方面发挥着关键作用。DC 具有异质性，存在具有不同功能的亚群。DC 的一个亚群，传统的 1 型 DC（cDC1），可以通过在小鼠中表达 CD8α/CD103 和在人类中表达 CD141 来定义，或者通过表达趋化因子受体 XCR1 来定义，XCR1 是在小鼠和人类中都保守的标志物。cDC1 的特点是摄取死亡细胞和交叉呈递抗原以产生细胞毒性 CD8 T 细胞反应的能力很高。通过这些活动，cDC1 在针对感染性病原体或肿瘤的免疫反应中发挥着至关重要的作用。同时，cDC1 在稳态情况下的作用还不完全清楚。使用缺失 cDC1 的突变小鼠进行的分析表明，cDC1 对于维持肠道免疫稳态至关重要。在这里，我们综述了 cDC1 的稳态作用，重点关注肠道免疫。
