2019冠状病毒病（COVID-19）感染后无合并症出院患者短期心理健康的相关性研究：一项前瞻性研究。
Correlation Study of Short-Term Mental Health in Patients Discharged After Coronavirus Disease 2019 (COVID-19) Infection without Comorbidities: A Prospective Study.
作者信息
Guo Lei, Lin Jingjing, Ying Weiyang, Zheng Chanfan, Tao Linshuang, Ying Binyu, Cheng Bihuan, Jin Shengwei, Hu Beilei
机构信息
Department of Critical Care Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People's Republic of China.
Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2020 Nov 6;16:2661-2667. doi: 10.2147/NDT.S278245. eCollection 2020.
OBJECTIVE
The WHO has upgraded the status of coronavirus disease 2019 (COVID-19) from epidemic to global pandemic. The psychometric properties aspects of COVID-19 patients without comorbidities in the short term after discharge have not been reported. In this study, the Short Form 36 (SF-36) was used to evaluate the psychometric properties and to find relevant risk factors.
METHODS
The study was conducted in seven hospitals from January 2020 to April 2020. The SF-36 questionnaire was administered one month after discharge. Univariate analysis and multivariate regression model were used to analyze the risk factors of psychometric properties impairment.
RESULTS
In univariate analysis of independent risk factors, according to the comparison of whether the duration of positive nucleic acid was greater than 20 days, the positive nucleic acid duration was independently related to the decreased role-emotional value [100, IQR (66-100) vs 100, IQR (0, 100); p = 0.0156]. In addition, multivariable linear regression model showed that male sex and positive nucleic acid duration were related to decreased role-emotional value (p = 0.03< 0.05; p = 0.01< 0.05, respectively). Mental health was associated with age (p= 0.0435). Subsequently, we divided into three subgroups: less than seven days, 7 to 14 days and more than 14 days according to the positive nucleic acid duration. The results revealed that there were significant differences in the vitality value and mental health value of patients aged 46 to 69 in the subgroup where the positive nucleic acid duration longer than 14 days (p= 0.0472; p= 0.0311< 0.05, respectively). Similarly, there are also significant differences in role-emotional value in different genders (p= 0.0316).
CONCLUSION
The study described the psychometric properties of COVID-19 patients without comorbidities shortly after discharge. Risk factors for psychometric properties damage included age, male sex, and nucleic acid duration.
目的
世界卫生组织已将2019冠状病毒病（COVID-19）的疫情状态从流行病升级为全球大流行。关于COVID-19出院后短期内无合并症患者的心理测量学特性方面尚未见报道。本研究采用简短健康调查问卷（SF-36）评估心理测量学特性并寻找相关危险因素。
方法
本研究于2020年1月至2020年4月在七家医院进行。出院一个月后发放SF-36问卷。采用单因素分析和多因素回归模型分析心理测量学特性受损的危险因素。
结果
在独立危险因素的单因素分析中，根据核酸阳性持续时间是否大于20天进行比较，核酸阳性持续时间与角色情感价值降低独立相关[100，四分位数间距（IQR）（66 - 100）对100，IQR（0，100）；p = 0.0156]。此外，多变量线性回归模型显示，男性和核酸阳性持续时间与角色情感价值降低有关（p = 0.03<0.05；p = 0.01<0.05）。心理健康与年龄相关（p = 0.0435）。随后，根据核酸阳性持续时间分为三个亚组：少于7天、7至14天和超过14天。结果显示，核酸阳性持续时间长于14天的亚组中，46至69岁患者的活力值和心理健康值存在显著差异（分别为p = 0.0472；p = 0.0311<0.05）。同样，不同性别在角色情感价值方面也存在显著差异（p = 0.0316）。
结论
本研究描述了COVID-19出院后短期内无合并症患者的心理测量学特性。心理测量学特性受损的危险因素包括年龄、男性和核酸持续时间。
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