雄激素与炎症在良性前列腺增生中的作用及相互关系的研究进展。
Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia.
机构信息
Department of Urology, Jing'an District Central Hospital, Fudan University, Shanghai 200040, China.
出版信息
Mediators Inflamm. 2020 Oct 28;2020:7958316. doi: 10.1155/2020/7958316. eCollection 2020.
Abstract
The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue.
摘要
良性前列腺增生（BPH）引起的下尿路症状（LUTS）和急性尿潴留（AUR）会严重影响老年男性的生活质量。研究表明，雄激素和炎症都会极大地影响大多数患者 BPH 的发生和发展。这两个因素还可以相互影响，导致 BPH 患者前列腺移行区的基质和上皮组织发生病理变化。BPH 患者前列腺组织中的 DHT 可能会激活前列腺中的慢性炎症反应，放大炎症因子的表达，并上调前列腺组织的增殖能力。
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