The Chinese University of Hong Kong (CUHK)-Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GDL), Advanced Institute for Regenerative MedicineBioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China.
Innovation Center for Translational Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Front Immunol. 2020 Oct 26;11:579687. doi: 10.3389/fimmu.2020.579687. eCollection 2020.
Accumulating evidence suggests that long non-coding RNA H19 correlates with several aging processes. However, the role of H19 in aging remains unclear. Many studies have elucidated a close connection between H19 and inflammatory genes. Chronic systemic inflammation is an established factor associated with various diseases during aging. Thus, H19 might participate in the development of age-related diseases by interplay with inflammation and therefore provide a protective function against age-related diseases. We investigated the inflammatory gene network of H19 to understand its regulatory mechanisms. H19 usually controls gene expression by acting as a microRNA sponge, or through mir-675, or by leading various protein complexes to genes at the chromosome level. The regulatory gene network has been intensively studied, whereas the biogenesis of H19 remains largely unknown. This literature review found that the epithelial-mesenchymal transition (EMT) and an imprinting gene network (IGN) might link H19 with inflammation. Evidence indicates that EMT and IGN are also tightly controlled by environmental stress. We propose that H19 is a stress-induced long non-coding RNA. Because environmental stress is a recognized age-related factor, inflammation and H19 might serve as a therapeutic axis to fight against age-related diseases.
越来越多的证据表明，长非编码 RNA H19 与几种衰老过程相关。然而，H19 在衰老中的作用仍不清楚。许多研究已经阐明了 H19 与炎症基因之间的密切联系。慢性系统性炎症是与衰老过程中各种疾病相关的已确定因素。因此，H19 可能通过与炎症的相互作用参与与年龄相关的疾病的发展，并因此提供对与年龄相关的疾病的保护作用。我们研究了 H19 的炎症基因网络，以了解其调节机制。H19 通常通过充当 microRNA 海绵，或通过 mir-675，或通过在染色体水平上将各种蛋白质复合物引导至基因来控制基因表达。调节基因网络已经得到了深入研究，而 H19 的生物发生仍然很大程度上未知。这篇文献综述发现，上皮-间充质转化 (EMT) 和印迹基因网络 (IGN) 可能将 H19 与炎症联系起来。有证据表明，EMT 和 IGN 也受到环境应激的严格控制。我们提出 H19 是一种应激诱导的长非编码 RNA。由于环境应激是公认的与年龄相关的因素，因此炎症和 H19 可能成为对抗与年龄相关的疾病的治疗轴。
