CINTESIS, NOVA Medical School, NMS, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.
CHRC, CEDOC, NOVA Medical School, NMS, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.
Nutrients. 2020 Nov 12;12(11):3469. doi: 10.3390/nu12113469.
Hand osteoarthritis (OA) is a degenerative joint disease which leads to pain and disability. Recent studies focus on the role of obesity and metabolic syndrome in inducing or worsening joint damage in hand OA patients, suggesting that chronic low-grade systemic inflammation may represent a possible linking factor. The gut microbiome has a crucial metabolic role which is fundamental for immune system development, among other important functions. Intestinal microbiota dysbiosis may favour metabolic syndrome and low-grade inflammation-two important components of hand OA onset and evolution. The aim of this narrative is to review the recent literature concerning the possible contribution of dysbiosis to hand OA onset and progression, and to discuss the importance of gut dysbiosis on general health and disease.
手部骨关节炎（OA）是一种退行性关节疾病，可导致疼痛和残疾。最近的研究集中在肥胖和代谢综合征在诱导或加重手部 OA 患者关节损伤中的作用，表明慢性低度全身炎症可能是一个可能的关联因素。肠道微生物组具有至关重要的代谢作用，对免疫系统的发育等重要功能至关重要。肠道微生物失调可能有利于代谢综合征和低度炎症——这是手部 OA 发病和进展的两个重要组成部分。本综述的目的是回顾有关肠道失调对手部 OA 发病和进展的可能贡献的最新文献，并讨论肠道失调对整体健康和疾病的重要性。
