Crisponi Guido, Nurchi Valeria Marina, Cappai Rosita, Zoroddu Maria Antonietta, Gerosa Clara, Piras Monica, Faa Gavino, Fanni Daniela
Department of Life and Environmental Sciences, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.
Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Curr Med Chem. 2021;28(35):7295-7311. doi: 10.2174/0929867327999201116195343.
A significant percentage of costs in pharmaceutical markets is devoted to supplements due to the confidence of consumers in the beneficial effects of these products. Magnesium is one of the supplements with enduring and increasing popularity. According to what is reported online, this metal ion can cure or prevent almost all kinds of diseases. This review aims at illustrating a series of scientifically demonstrated cases in which magnesium was used in clinical practice. Except for its ordinary use as antacid and laxative, other ascertained uses, reported in scientific literature, consist of helping to treat several diseases such as nocturnal leg cramps, pre-eclampsia, diabetes, depression, Parkinson's and Alzheimer's disease, hypertension, some types of arrhythmias, asthma, migraine headaches, epilepsy, cerebral haemorrhage, and stroke. However, many of these promising uses of magnesium require further studies to define the involved molecular mechanisms which should help establishing its uses in relation to the prolonged use of supplements.
由于消费者对这些产品有益效果的信任，药品市场中有很大一部分成本用于补充剂。镁是一种经久不衰且越来越受欢迎的补充剂。据网上报道，这种金属离子几乎可以治愈或预防所有种类的疾病。本综述旨在阐述一系列科学证实的镁在临床实践中应用的案例。除了作为抗酸剂和泻药的常规用途外，科学文献中报道的其他已确定用途包括帮助治疗多种疾病，如夜间腿部痉挛、先兆子痫、糖尿病、抑郁症、帕金森病和阿尔茨海默病、高血压、某些类型的心律失常、哮喘、偏头痛、癫痫、脑出血和中风。然而，镁的许多这些有前景的用途需要进一步研究来确定其中涉及的分子机制，这将有助于确定其在补充剂长期使用方面的用途。
