Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
J Anim Sci. 2020 Dec 1;98(12). doi: 10.1093/jas/skaa366.
Selenium (Se) is an essential trace element for animals and exists in nature in both inorganic and organic forms. Although organic Se is more bioavailable than inorganic Se, there are inconsistent reports on the effect of organic Se on the reproductive performance of sows. This study was conducted to investigate the effect of maternal organic Se (2-hydroxy-4-methylselenobutanoic [HMSeBA]) supplementation on reproductive performance and antioxidant capacity of sows, and the long-term effect on the growth performance and antioxidant capacity of their offspring with or without lipopolysaccharide (LPS) challenge. The experimental design used in this study was a completely randomized design; 45 Landrace × Yorkshire sows were randomly allocated to receive one of the following three diets during gestation: control diet (Control, basal diet, n = 15), sodium selenite (Na2SeO3)-supplemented diet (Na2SeO3, basal diet + 0.3 mg Se/kg Na2SeO3, n = 15), and HMSeBA-supplemented diet (HMSeBA, basal diet + 0.3 mg Se/kg HMSeBA, n = 15). On day 21 of age, male offspring from each group were injected with LPS or saline (n = 6). As compared with the control group, maternal HMSeBA supplementation increased the number of total born piglets, while decreased birth weight (P < 0.05). In the first week of lactation, maternal HMSeBA supplementation increased litter weight gain compared with the Na2SeO3 group (P < 0.05) and increased the average daily gain of piglets compared with the control group and Na2SeO3 group (P < 0.05). Meanwhile, maternal HMSeBA supplementation decreased piglet birth interval as compared with the control group and Na2SeO3 group (P < 0.05). Besides, plasma glutathione peroxidase (GSH-Px) activity was higher in the HMSeBA group on farrowing 0 min and 90 min, while malondialdehyde (MDA) concentration was lower on farrowing 0, 90, and 135 min than those in the control group (P < 0.05). In addition, maternal HMSeBA supplementation increased the concentration of selenoprotein P (SELENOP) in colostrum compared with the control group (P < 0.05). Further study revealed that the LPS-challenged HMSeBA group had higher GSH-Px and total antioxidant capacity and lower MDA in weaning piglets compared with the LPS-challenged control group (P < 0.05). Taken together, maternal HMSeBA supplementation increased the number of total born piglets, shortened the duration of farrowing, improved the antioxidant capacities of sows and their offspring, and improved the growth performance of suckling pigs at the first week of lactation. Thus, HMSeBA supplementation during gestation has the potentiality to produce more kilogram of meat.
硒（Se）是动物必需的微量元素，以无机和有机两种形式存在于自然界中。虽然有机硒比无机硒更具生物利用度，但关于有机硒对母猪繁殖性能的影响，报告结果并不一致。本研究旨在探讨母体有机硒（2-羟基-4-甲基硒丁基丁酸[HMSeBA]）补充对母猪繁殖性能和抗氧化能力的影响，以及在有无脂多糖（LPS）挑战的情况下，对其后代生长性能和抗氧化能力的长期影响。本研究采用完全随机设计，将 45 头长白 × 约克夏母猪随机分配到妊娠期间接受以下三种饮食之一：对照组（Control，基础日粮，n = 15）、亚硒酸钠（Na2SeO3）补充组（Na2SeO3，基础日粮+0.3 mg/kg Na2SeO3，n = 15）和 HMSeBA 补充组（HMSeBA，基础日粮+0.3 mg/kg HMSeBA，n = 15）。在第 21 天龄时，每组雄性后代均接受 LPS 或生理盐水注射（n = 6）。与对照组相比，母体 HMSeBA 补充增加了总产仔数，而降低了初生重（P < 0.05）。在哺乳期第一周，与 Na2SeO3 组相比，母体 HMSeBA 补充增加了窝重增重（P < 0.05），与对照组和 Na2SeO3 组相比，增加了仔猪的平均日增重（P < 0.05）。同时，与对照组和 Na2SeO3 组相比，母体 HMSeBA 补充减少了仔猪的出生间隔（P < 0.05）。此外，分娩 0 min 和 90 min 时，HMSeBA 组血浆谷胱甘肽过氧化物酶（GSH-Px）活性较高，而分娩 0、90 和 135 min 时丙二醛（MDA）浓度均低于对照组（P < 0.05）。此外，与对照组相比，母体 HMSeBA 补充增加了初乳中硒蛋白 P（SELENOP）的浓度（P < 0.05）。进一步研究表明，与 LPS 挑战的对照组相比，LPS 挑战的 HMSeBA 组断奶仔猪的 GSH-Px 和总抗氧化能力更高，MDA 水平更低（P < 0.05）。综上所述，母体 HMSeBA 补充增加了总产仔数，缩短了分娩时间，提高了母猪及其后代的抗氧化能力，提高了哺乳期第一周仔猪的生长性能。因此，妊娠期间补充 HMSeBA 有可能生产更多的肉。
