Dorea J G, Brito M, Araujo M O
Laboratory of Nutrition, Faculty of Health Sciences, University of Brasilia, DF Brazil.
J Am Coll Nutr. 1987 Dec;6(6):491-5. doi: 10.1080/07315724.1987.10720208.
Hepatic concentrations of copper (Cu) and zinc (Zn) were studied in 38 fetuses and infants, who died of various causes, from 26 weeks of gestation up to 16 weeks post-natally. The six fetuses of 28-32 weeks gestation had median and mean hepatic Cu concentrations micrograms/g fresh tissue) comparable to those found in the 21 born at term, but the range of values was much narrower: all of the Cu values for those born prematurely were at or below 40 micrograms/g. Values at 10 micrograms/g and below were found in five infants at term and five who died at 1-4 months of age. There was a comparable range of Zn values for both pre-term and term babies (10 to 300 micrograms/g fresh tissue). The value of 10 micrograms/g was found only in one 4-month-old infant. The accumulation of both Cu and Zn occurs independently in the fetuses. The socioeconomic status did not influence significantly the concentration of liver Cu or Zn in babies born at term. However, size of babies as measured by liver weight showed that larger babies had significantly higher mean Cu concentration (37 +/- 24 micrograms/g) than smaller babies (21 +/- 14 micrograms/g. The same trend, but without significant difference, was observed for hepatic Zn between larger (104 +/- 78 micrograms/g) and smaller (74 +/- 59 micrograms/g babies.
对38例因各种原因死亡的胎儿和婴儿（妊娠26周直至出生后16周）的肝脏铜（Cu）和锌（Zn）浓度进行了研究。妊娠28 - 32周的6例胎儿肝脏铜浓度（微克/克新鲜组织）的中位数和平均值与21例足月出生者相当，但数值范围窄得多：所有早产者的铜值均在40微克/克及以下。足月出生的5例婴儿和1 - 4个月龄死亡的5例婴儿中发现有铜值在10微克/克及以下的情况。早产和足月婴儿的锌值范围相当（10至300微克/克新鲜组织）。仅在1例4个月龄婴儿中发现锌值为10微克/克。胎儿体内铜和锌的蓄积是独立发生的。社会经济状况对足月出生婴儿肝脏铜或锌的浓度没有显著影响。然而，以肝脏重量衡量的婴儿大小显示，较大婴儿的平均铜浓度（37±24微克/克）显著高于较小婴儿（21±14微克/克）。较大婴儿（104±78微克/克）和较小婴儿（74±59微克/克）的肝脏锌含量也观察到相同趋势，但无显著差异。
