Nader Marta Guilherme, Munhoz Rodrigo Ramella, Teixeira Monica La Porte, Waldvogel Bernadette Cunha, Pires de Camargo Veridiana, Feher Olavo, Sanches Jose Antonio
Medical Oncology Service, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Oncologia D'Or, Rio de Janeiro, Brazil.
JCO Glob Oncol. 2020 Nov;6:1766-1771. doi: 10.1200/GO.20.00426.
A substantial increase in melanoma incidence has been consistently observed worldwide over the past decades. However, melanoma mortality rates have remained stable or declined over the past years in most regions. Given the paucity of melanoma mortality data for different Brazilian regions, we sought to describe melanoma mortality trends in southeastern Brazil and their relationship with demographic variables.
A cross-sectional registry-based analysis was conducted to describe melanoma mortality trends in the state of São Paulo, Brazil, from 1996 to 2016. Demographic information from melanoma-related death records, including sex and age, was collected from the Fundação Sistema Estadual de Análise de Dados database. The annual percentage change (APC) was calculated to identify mortality trends over the period.
An increasing melanoma mortality trend was detected among males, regardless of age (APC, 1.72%; < .001), and was more pronounced for men ≥ 60 years old (APC, 2.63%; < .001). Melanoma mortality rates have also increased for patients ≥ 60 years old, regardless of sex (APC, 1.11%; < .001). A non-statistically significant increase in the overall melanoma mortality rate was observed over the 20-year period analyzed (APC, 0.36%; = .4).
Our data suggest a stable melanoma mortality over the past two decades for the overall population studied; however, a significant increase in melanoma mortality rates has been demonstrated among males and in the population ≥ 60 years old, emphasizing the need to implement prevention strategies and expand access to effective therapies for this population.
在过去几十年中，全球黑色素瘤发病率持续大幅上升。然而，在大多数地区，黑色素瘤死亡率在过去几年中一直保持稳定或有所下降。鉴于巴西不同地区黑色素瘤死亡率数据匮乏，我们试图描述巴西东南部黑色素瘤死亡率趋势及其与人口统计学变量的关系。
进行了一项基于登记处的横断面分析，以描述1996年至2016年巴西圣保罗州黑色素瘤死亡率趋势。从巴西国家数据分析基金会数据库收集黑色素瘤相关死亡记录中的人口统计学信息，包括性别和年龄。计算年度百分比变化（APC）以确定该时期的死亡率趋势。
无论年龄大小，男性黑色素瘤死亡率呈上升趋势（APC，1.72%；P <.001），60岁及以上男性更为明显（APC，2.63%；P <.001）。60岁及以上患者的黑色素瘤死亡率也有所上升，无论性别如何（APC，1.11%；P <.001）。在分析的20年期间，总体黑色素瘤死亡率有非统计学意义的增加（APC，0.36%；P =.4）。
我们的数据表明，在所研究的总体人群中，过去二十年黑色素瘤死亡率稳定；然而，男性和60岁及以上人群的黑色素瘤死亡率显著增加，强调需要实施预防策略并扩大该人群获得有效治疗的机会。
