Özgök Kangal Kübra, Özgök Yaşar
Department of Undersea and Hyperbaric Medicine, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey.
Department of Urology, Yüksek İhtisas University Faculty of Medicine, Ankara, Turkey.
Turk J Urol. 2021 Mar;47(2):98-105. doi: 10.5152/tud.2020.20328. Epub 2020 Oct 30.
This study aimed to analyze the results of hyperbaric oxygen therapy (HBOT) in addition to assisted reproductive technologies in male infertility cases.
Medical records of male infertility patients who had HBOT sessions for any reason between January 1, 2015-December 31, 2019, were analyzed retrospectively.
A total of 15 male patients were included. Patients were classified as group 1 [DNA fragmentation (n=5)], group 2 [globozoospermia (n=5)], and group 3 [azoospermia (n=5)]. Round spermatid injection (ROSI), intrauterine insemination (IUI), or intracytoplasmic sperm injection (ICSI) procedures were performed in 10 of the 15 patients. A total of 31 embryos were obtained out of which 19 (61%) were transferred. While a total of 15 embryos were obtained in the globozoospermic group, which was the highest number, 10 were obtained from the azoospermic patients, and 6 from the DNA fragmentation patients (p=0.515). A total of 3 (30%) healthy pregnancies were obtained, overall. The mean sperm count of the patients (n=9) before HBOT was 8.4±11.1 mil/mL, while it was found to be 15.7±15.0 mil/mL after HBOT (azoospermic patients were not included). The TESE results were analyzed for azoospermic patients; positive changes were observed in 4 patients (80%). On the other hand, there was an improvement in 50% of group 1 according to sperm DNA fragmentation after HBOT (p=0.500).
While a total of 15 embryos were obtained in the globozoospermic group, which was the highest number, 10 were obtained from the azoospermic patients.. Further studies should be conducted on HBOT and male infertility.
本研究旨在分析高压氧疗法（HBOT）联合辅助生殖技术治疗男性不育症的效果。
回顾性分析2015年1月1日至2019年12月31日期间因任何原因接受过HBOT治疗的男性不育患者的病历。
共纳入15例男性患者。患者分为1组[DNA碎片率高（n = 5）]、2组[圆头精子症（n = 5）]和3组[无精子症（n = 5）]。15例患者中有10例接受了圆形精子细胞注射（ROSI）、宫内人工授精（IUI）或卵胞浆内单精子注射（ICSI）。共获得31个胚胎，其中19个（61%）被移植。圆头精子症组获得的胚胎总数最多，为15个，无精子症患者获得10个，DNA碎片率高的患者获得6个（p = 0.515）。总体上共获得3例（30%）健康妊娠。HBOT治疗前患者（n = 9）的平均精子计数为8.4±11.1百万/毫升，HBOT治疗后为15.7±15.0百万/毫升（无精子症患者未纳入）。分析了无精子症患者的睾丸切开取精术（TESE）结果；4例患者（80%）观察到阳性变化。另一方面，根据精子DNA碎片率，HBOT治疗后1组中有50%的患者有所改善（p = 0.500）。
圆头精子症组获得的胚胎总数最多，为15个，无精子症患者获得10个。应进一步开展关于HBOT与男性不育症的研究。
