State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Innovatus Oral Cosmetic & Surgical Institute, Norman, OK 73069, USA.
Int J Biol Macromol. 2021 Jan 15;167:1198-1210. doi: 10.1016/j.ijbiomac.2020.11.073. Epub 2020 Nov 14.
Chitosan is a biodegradable and biocompatible natural polysaccharide that has a wide range of applications in the field of dentistry due to its functional versatility and ease of access. Recent studies find that chitosan and its derivatives can be embedded in materials for dental adhesives, barrier membranes, bone replacement, tissue regeneration, and antimicrobial agent to better manage oral diseases. In this paper, we provide a comprehensive overview on the preparation, applications, and major breakthroughs of chitosan biomaterials. Furthermore, incorporation of chitosan additives for the modification and improvement of dental materials has been discussed in depth to promote more advanced chitosan-related research in the future.
壳聚糖是一种可生物降解和生物相容的天然多糖，由于其功能多样性和易于获得，在牙科领域有广泛的应用。最近的研究发现，壳聚糖及其衍生物可以嵌入到牙科用胶粘剂、屏障膜、骨替代物、组织再生和抗菌剂等材料中，以更好地治疗口腔疾病。本文对壳聚糖生物材料的制备、应用和主要突破进行了全面概述。此外，还深入讨论了壳聚糖添加剂在牙科材料改性和改进中的应用，以促进未来更先进的壳聚糖相关研究。
