Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR, 72079, USA.
Biological Science Department, College of Science, King Abdul-Aziz University, Jeddah, Saudi Arabia.
BMC Microbiol. 2020 Nov 17;20(1):353. doi: 10.1186/s12866-020-02008-x.
In the past decade, the initial studies of the gut microbiota started focusing on the correlation of the composition of the gut microbiota and the health or diseases of the host, and there are extensive literature reviews pertaining to this theme. However, little is known about the association between the microbiota, the host, and pathogenic bacteria, such as Salmonella enterica, which is among the most important foodborne pathogens and identified as the source of multiple outbreaks linked to contaminated foods causing salmonellosis. Secretion systems, flagella, fimbriae, endotoxins, and exotoxins are factors that play the most important roles in the successful infection of the host cell by Salmonella. Infections with S. enterica, which is a threat to human health, can alter the genomic, taxonomic, and functional traits of the gut microbiota. The purpose of this review is to outline the state of knowledge on the impacts of S. enterica on the intestinal microbiota and highlight the need to identify the gut bacteria that could contribute to salmonellosis.
在过去的十年中，肠道微生物组的初步研究开始关注肠道微生物组的组成与宿主健康或疾病之间的相关性，并且有大量相关的文献综述。然而，对于微生物组、宿主和致病菌（如沙门氏菌）之间的关联知之甚少，沙门氏菌是最重要的食源性病原体之一，被认为是多种与污染食物有关的暴发事件的源头，这些事件可导致沙门氏菌病。分泌系统、鞭毛、菌毛、内毒素和外毒素是沙门氏菌成功感染宿主细胞的最重要因素。感染对人类健康构成威胁的沙门氏菌会改变肠道微生物组的基因组、分类和功能特征。本综述旨在概述沙门氏菌对肠道微生物组影响的现有知识，并强调需要确定可能导致沙门氏菌病的肠道细菌。
