NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA.
BMC Res Notes. 2020 Nov 17;13(1):538. doi: 10.1186/s13104-020-05356-z.
Low back pain (LBP) is one of the most disabling and costly conditions worldwide. It remains unclear why many individuals experience persistent and recurrent symptoms after an acute episode whereas others do not. A longitudinal cohort study was established to address this problem. We aimed to; (1) evaluate whether promising and potentially modifiable biological, psychological, social and behavioural factors, along with their possible interactions, predict LBP outcome after an acute episode; (2) compare these factors between individuals with and without acute LBP; and (3) evaluate the time-course of changes in these factors from LBP onset. This paper outlines the methodology and compares baseline characteristics between acute LBP and control, and LBP participants with and without follow-up.
133 individuals with acute LBP and 74 pain-free individuals participated. Bio-psycho-social and behavioural measures were collected at baseline and 3-monthly for 12 months (LBP) or 3 months (control). Pain and disability were recorded fortnightly. Baseline characteristics were mostly similar between those who did and did not return for follow-up. Initial analyses of this cohort have revealed important insights into the pathways involved in acute-to-chronic LBP. These and future findings will provide new targets for treatment and prevention of persistent and recurrent LBP.
下背痛（LBP）是全球最具致残性和高成本的疾病之一。仍不清楚为什么许多人在急性发作后会出现持续和反复的症状，而另一些人则不会。本研究建立了一个纵向队列研究来解决这个问题。我们旨在：（1）评估有希望且可能具有可调节性的生物、心理、社会和行为因素，以及它们可能的相互作用，是否可以预测急性发作后的 LBP 结局；（2）比较急性 LBP 患者与无 LBP 患者之间的这些因素；（3）评估这些因素从 LBP 发病开始的变化过程。本文概述了方法学，并比较了急性 LBP 和对照组、有和无随访的 LBP 参与者之间的基线特征。
133 名急性 LBP 患者和 74 名无疼痛者参与了研究。在基线和 3 个月时收集了生物心理社会和行为测量数据，并在 12 个月（LBP）或 3 个月（对照组）时进行了随访。疼痛和残疾每两周记录一次。有和没有随访的参与者之间的基线特征大多相似。对该队列的初步分析揭示了急性到慢性 LBP 涉及的途径的重要见解。这些和未来的研究结果将为持续性和复发性 LBP 的治疗和预防提供新的目标。
