TAD 怀疑论者：三维基因组拓扑结构是否保守？
A TAD Skeptic: Is 3D Genome Topology Conserved?
机构信息
Department of Human Genetics, University of Chicago, Cummings Life Science Center, 928 E. 58th St., Chicago, IL 60637, USA.
Department of Human Genetics, University of Chicago, Cummings Life Science Center, 928 E. 58th St., Chicago, IL 60637, USA; Section of Genetic Medicine, Department of Medicine, University of Chicago, 5841 S. Maryland Ave., N417, MC6091, Chicago, IL 60637, USA.
出版信息
Trends Genet. 2021 Mar;37(3):216-223. doi: 10.1016/j.tig.2020.10.009. Epub 2020 Nov 14.
Abstract
The notion that topologically associating domains (TADs) are highly conserved across species is prevalent in the field of 3D genomics. However, what exactly is meant by 'highly conserved' and what are the actual comparative data that support this notion? To address these questions, we performed a historical review of the relevant literature and retraced numerous citation chains to reveal the primary data that were used as the basis for the widely accepted conclusion that TADs are highly conserved across evolution. A thorough review of the available evidence suggests the answer may be more complex than what is commonly presented.
摘要
结构域关联（TAD）在物种间高度保守的观点在三维基因组学领域非常流行。然而，“高度保守”的确切含义是什么，以及支持这一观点的实际比较数据是什么？为了解决这些问题，我们对相关文献进行了历史回顾，并追溯了许多引文链，以揭示被广泛接受的 TAD 在进化中高度保守的这一结论所依据的主要数据。对现有证据的全面审查表明，答案可能比通常呈现的更为复杂。
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