Connaire Jeffrey J, Sundermann Matthew L, Perumal Ramu, Herzog Charles A
Davita Clinical Research, Minneapolis, MN, USA.
ZOLL, Pittsburgh, PA, USA.
Med Devices (Auckl). 2020 Nov 11;13:377-383. doi: 10.2147/MDER.S277159. eCollection 2020.
Fluid monitoring is an important management strategy in patients with chronic kidney disease (CKD) and heart failure (HF). The µCor™ Heart Failure and Arrhythmia Management System uses a radiofrequency-based thoracic fluid index (TFI) to track pulmonary edema. During hemodialysis, the acute removal of fluid through ultrafiltration offers a model for measuring a patient's fluid status. The objective of the study was to assess the relationship between the device measured TFI and ultrafiltration volume (UFV).
Patients undergoing chronic dialysis with and without heart failure were enrolled in the study. The relationship between TFI and UFV in each individual subject was assessed by calculating the Pearson correlation coefficient (). The average correlation across all subjects was calculated through the use of the Fisher's transform. Responder analysis was performed to assess the magnitude of change in TFI before and after dialysis.
Twenty subjects were enrolled in the trial. The mean volume of fluid removal was 3.63 L (SD 0.88 L). The mean correlation based on Fisher's transform was 0.95 CI (0.92-0.99). Responder analysis showed that the mean reduction of TFI after dialysis was 5.5% ± 3.8.
The µCor system provides radiofrequency-based measurements of thoracic fluid which correlate well with total body fluid removal in a real-world setting. Fluid management based on the radar-derived TFI may provide benefits to dialysis patients and serves as a potential model for pulmonary edema common to the clinical course of heart failure.
液体监测是慢性肾脏病（CKD）和心力衰竭（HF）患者重要的管理策略。µCor™心力衰竭与心律失常管理系统使用基于射频的胸液指数（TFI）来追踪肺水肿情况。在血液透析期间，通过超滤急性清除液体为测量患者的液体状态提供了一个模型。本研究的目的是评估该设备测量的TFI与超滤量（UFV）之间的关系。
设计、设置、参与者与测量方法：纳入接受慢性透析且伴有或不伴有心力衰竭的患者。通过计算Pearson相关系数（）评估每个个体受试者中TFI与UFV之间的关系。通过使用Fisher变换计算所有受试者的平均相关性。进行反应者分析以评估透析前后TFI的变化幅度。
20名受试者纳入试验。平均液体清除量为3.63L（标准差0.88L）。基于Fisher变换的平均相关性为0.95 CI（0.92 - 0.99）。反应者分析显示透析后TFI的平均降低为5.5%±3.8。
µCor系统提供基于射频的胸液测量，在实际环境中与全身液体清除情况相关性良好。基于雷达衍生的TFI进行液体管理可能对透析患者有益，并可作为心力衰竭临床过程中常见肺水肿的潜在模型。
