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媒介体内寄生虫发育对外潜伏期的影响。

The impact of within-vector parasite development on the extrinsic incubation period.

作者信息

Childs Lauren M, Prosper Olivia F

机构信息

Department of Mathematics, Virginia Tech, 225 Stanger St, Blacksburg, VA 24060, USA.

Department of Mathematics, University of Tennessee, 1403 Circle Dr, Knoxville, TN 37996, USA.

出版信息

R Soc Open Sci. 2020 Oct 7;7(10):192173. doi: 10.1098/rsos.192173. eCollection 2020 Oct.

DOI:10.1098/rsos.192173
PMID:33204441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7657899/
Abstract

Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the mosquito, to complete its full life cycle. Here, we focus on the parasite dynamics within the vector to examine the first appearance of sporozoites in the salivary glands, which indicates a first time of infectiousness of mosquitoes. The timing of this period of pathogen development in the mosquito until transmissibility, known as the extrinsic incubation period, remains poorly understood. We develop compartmental models of within-mosquito parasite dynamics fitted with experimental data on oocyst and sporozoite counts. We find that only a fraction of oocysts burst to release sporozoites and bursting must be delayed either via a time-dependent function or a gamma-distributed set of compartments. We use Bayesian inference to estimate distributions of parameters and determine that bursting rate is a key epidemiological parameter. A better understanding of the factors impacting the extrinsic incubation period will aid in the development of interventions to slow or stop the spread of malaria.

摘要

蚊媒疾病,尤其是疟疾,在全球造成了沉重负担,每年导致近50万人死亡。疟原虫需要脊椎动物宿主(如人类)和媒介宿主(蚊子)来完成其完整的生命周期。在这里,我们关注疟原虫在媒介体内的动态变化,以研究子孢子在唾液腺中的首次出现,这标志着蚊子首次具有传染性。蚊子体内病原体从发育到具有传播能力的这段时间,即所谓的外在潜伏期,目前仍知之甚少。我们建立了蚊子体内疟原虫动态变化的 compartmental 模型,并结合了关于卵囊和子孢子数量的实验数据。我们发现,只有一小部分卵囊破裂释放子孢子,并且破裂必须通过时间依赖函数或一组伽马分布的区室来延迟。我们使用贝叶斯推理来估计参数分布,并确定破裂率是一个关键的流行病学参数。更好地了解影响外在潜伏期的因素将有助于制定减缓或阻止疟疾传播的干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/7ca54215f8a3/rsos192173-g7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/155e5fc94713/rsos192173-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/257dcab53136/rsos192173-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/7ca54215f8a3/rsos192173-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/9616e9ddfe81/rsos192173-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/905a3117570a/rsos192173-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/c254374d0052/rsos192173-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/dba095ded959/rsos192173-g4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/257dcab53136/rsos192173-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f39/7657899/7ca54215f8a3/rsos192173-g7.jpg

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