Wang Yijia, Zhang Chunze, Hou Shaobin, Wu Xiaojing, Liu Jun, Wan Xuehua
Laboratory of Oncologic Molecular Medicine, Tianjin Union Medical Center, Nankai University, Tianjin, People's Republic of China.
Department of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin, People's Republic of China.
Cancer Manag Res. 2020 Nov 12;12:11553-11561. doi: 10.2147/CMAR.S275316. eCollection 2020.
Besides genetic and epigenetic alterations that lead to carcinogenesis and development of colorectal cancer (CRC), intestinal microbiomes are recently recognized to play a critical role in CRC progression. The abundant species associated with human CRC have been proposed for their roles in promoting tumorigenesis. However, a recent "driver-passenger" model suggests that these CRC-associated species with high relative abundances may be passenger bacteria that take advantage of the tumor environment instead of initiating CRC, whereas the driver species that initiate CRC have been replaced by passenger bacteria due to the alteration of the intestinal niche.
Here, to reveal potential driver and passenger bacteria during CRC progression, we compare the gut mucosal microbiomes of 75 triplet-paired CRC samples collected from on-tumor site, adjacent-tumor site, and off-tumor site, and 26 healthy controls.
Our analyses revealed potential driver bacteria in four genera and two families, and potential passenger bacteria in 14 genera or families. and were predicted to be potential driver bacteria. Moreover, 14 potential passenger bacteria were identified and divided into five groups. Group I passenger bacteria contain , and . Group II passenger bacteria contain . Group III passenger bacteria contain . Group IV passenger bacteria contain , and . Group V passenger bacteria contain . Co-occurrence network analysis reveals a low correlation relationship between driver and passenger bacteria in CRC patients compared with healthy controls.
These driver and passenger species may serve as bio-marker species for screening cohorts with high risk to initiate CRC or patients with CRC, respectively. Further functional studies will help understand the roles of driver and passenger bacteria in CRC initiation and development.
除了导致结直肠癌（CRC）发生和发展的基因和表观遗传改变外，肠道微生物群最近被认为在CRC进展中起关键作用。与人类CRC相关的丰富物种因其在促进肿瘤发生中的作用而被提出。然而，最近的一种“驱动-乘客”模型表明，这些相对丰度高的与CRC相关的物种可能是利用肿瘤环境的乘客细菌，而不是引发CRC的细菌，而由于肠道生态位的改变，引发CRC的驱动细菌已被乘客细菌所取代。
在这里，为了揭示CRC进展过程中的潜在驱动和乘客细菌，我们比较了从肿瘤部位、肿瘤相邻部位和肿瘤外部位收集的75个三联配对CRC样本以及26个健康对照的肠道黏膜微生物群。
我们的分析揭示了4个属和2个科中的潜在驱动细菌，以及14个属或科中的潜在乘客细菌。[具体属名]和[具体属名]被预测为潜在驱动细菌。此外，鉴定出14种潜在乘客细菌并分为五组。第一组乘客细菌包含[具体菌名]、[具体菌名]和[具体菌名]。第二组乘客细菌包含[具体菌名]。第三组乘客细菌包含[具体菌名]。第四组乘客细菌包含[具体菌名]和[具体菌名]。第五组乘客细菌包含[具体菌名]。共现网络分析显示，与健康对照相比，CRC患者中驱动和乘客细菌之间的相关性较低。
这些驱动和乘客物种可能分别作为生物标志物物种，用于筛查具有高CRC发病风险的队列或CRC患者。进一步的功能研究将有助于了解驱动和乘客细菌在CRC起始和发展中的作用。
