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肠道黏膜微生物群特征与结直肠癌复发相关。

Gut mucosal microbiota profiles linked to colorectal cancer recurrence.

机构信息

Department of Oncology, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China.

Laboratory of Oncologic Molecular Medicine, Tianjin Union Medical Center, Nankai University, Tianjin 300121, China.

出版信息

World J Gastroenterol. 2022 May 14;28(18):1946-1964. doi: 10.3748/wjg.v28.i18.1946.

DOI:10.3748/wjg.v28.i18.1946
PMID:35664963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9150055/
Abstract

BACKGROUND

Emerging evidence links gut microbiota to various human diseases including colorectal cancer (CRC) initiation and development. However, gut microbiota profiles associated with CRC recurrence and patient prognosis are not completely understood yet, especially in a Chinese cohort.

AIM

To investigate the relationship between gut mucosal microbiota profiles and CRC recurrence and patient prognosis.

METHODS

We obtained the composition and structure of gut microbiota collected from 75 patients diagnosed with CRC and 26 healthy controls. The patients were followed up by regular examination to determine whether tumors recurred. Triplet-paired samples from on-tumor, adjacent-tumor and off-tumor sites of patients diagnosed with/without CRC recurrence were analyzed to assess spatial-specific patterns of gut mucosal microbiota by 16S ribosomal RNA sequencing. Next, we carried out bioinformatic analyses, Kaplan-Meier survival analyses and Cox regression analyses to determine the relationship between gut mucosal microbiota profiles and CRC recurrence and patient prognosis.

RESULTS

We observed spatial-specific patterns of gut mucosal microbiota profiles linked to CRC recurrence and patient prognosis. A total of 17 bacterial genera/families were identified as potential biomarkers for CRC recurrence and patient prognosis, including , , , , , , , , , , , , , , , TG5 and .

CONCLUSION

Our work suggests that intestinal microbiota can serve as biomarkers to predict the risk of CRC recurrence and patient death.

摘要

背景

越来越多的证据表明肠道微生物群与各种人类疾病有关，包括结直肠癌（CRC）的发生和发展。然而，与 CRC 复发和患者预后相关的肠道微生物群谱尚不完全清楚，尤其是在中国人群中。

目的

研究肠道黏膜微生物群谱与 CRC 复发和患者预后的关系。

方法

我们获得了 75 例 CRC 患者和 26 例健康对照者的肠道微生物群组成和结构。通过定期检查来确定肿瘤是否复发，对诊断为/未诊断为 CRC 复发的患者的肿瘤、肿瘤旁和远离肿瘤的三联配对样本进行分析，通过 16S 核糖体 RNA 测序来评估肠道黏膜微生物群的空间特异性模式。然后，我们进行了生物信息学分析、Kaplan-Meier 生存分析和 Cox 回归分析，以确定肠道黏膜微生物群谱与 CRC 复发和患者预后的关系。

结果

我们观察到与 CRC 复发和患者预后相关的肠道黏膜微生物群谱的空间特异性模式。共鉴定出 17 个细菌属/科可能作为 CRC 复发和患者预后的生物标志物，包括 、 、 、 、 、 、 、 、 、 、 、TG5 和 。

结论

我们的工作表明肠道微生物群可以作为预测 CRC 复发和患者死亡风险的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/368ef1c33c6c/WJG-28-1946-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/ec72252c5a95/WJG-28-1946-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/f7f4f829252a/WJG-28-1946-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/bfb230016942/WJG-28-1946-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/e772e2d61a44/WJG-28-1946-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/23d0a002a9db/WJG-28-1946-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/368ef1c33c6c/WJG-28-1946-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/ec72252c5a95/WJG-28-1946-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/f7f4f829252a/WJG-28-1946-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/bfb230016942/WJG-28-1946-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/e772e2d61a44/WJG-28-1946-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/23d0a002a9db/WJG-28-1946-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d90a/9150055/368ef1c33c6c/WJG-28-1946-g006.jpg

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