Agbele Alaba Tolulope, Fasoro Olatunji Jimoh, Fabamise Olufemi Moses, Oluyide Oluwabusayo Odunola, Idolor Omena Raphael, Bamise Esther Abosede
Department of Medical Physics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Basic Medical Sciences, College of Health Sciences and Technology, Ijero-Ekiti, Ekiti State, Nigeria.
Eurasian J Med. 2020 Oct;52(3):298-303. doi: 10.5152/eurasianjmed.2020.20143.
The use of some agents as radioprotectors has been evaluated for protection against normal tissue toxicity following exposure to ionizing radiation. Resveratrol, a natural flavonoid, with antioxidant and anti-inflammatory properties has attracted research interests for its radioprotective potential. This study systematically evaluates existing studies to examine the radioprotective effectiveness of resveratrol. A literature search of the electronic databases, including PubMed, Scopus, and Embase was conducted to retrieve articles investigating the protective effect of resveratrol against ionizing radiation-induced damage to normal tissues. The search timeframe ranged from the inception of each database to January 2020. From an initial search of 231 articles, and after the removal of duplicates as well as applying the predetermined inclusion and exclusion criteria, 33 articles were finally included for this systematic review. Results showed promising protective effect of resveratrol against ionizing radiation-induced damage to normal tissues. Furthermore, no adverse effect was observed after administering resveratrol. Resveratrol showed the potential to protect against ionizing radiation-induced damage to normal tissue cells via notable mechanisms, including anti-apoptotic and anti-inflammatory effects. However, further studies on the efficacy of clinical translation of resveratrol would open up more insights, while other gray areas such as the optimal radioprotective dosage of resveratrol requires further investigation. Overall, resveratrol is a potential double-edged sword in cancer therapy while protecting healthy tissues.
一些药剂作为辐射防护剂的用途已被评估，以保护机体免受电离辐射后正常组织的毒性影响。白藜芦醇是一种天然黄酮类化合物，具有抗氧化和抗炎特性，其辐射防护潜力已引起研究兴趣。本研究系统评价现有研究，以检验白藜芦醇的辐射防护效果。通过检索包括PubMed、Scopus和Embase在内的电子数据库，获取研究白藜芦醇对电离辐射所致正常组织损伤保护作用的文章。检索时间范围为各数据库建库至2020年1月。初步检索到231篇文章，在去除重复文章并应用预定的纳入和排除标准后，最终纳入33篇文章进行本系统评价。结果表明，白藜芦醇对电离辐射所致正常组织损伤具有显著的保护作用。此外，给予白藜芦醇后未观察到不良反应。白藜芦醇显示出通过显著机制，包括抗凋亡和抗炎作用，来保护正常组织细胞免受电离辐射损伤的潜力。然而，关于白藜芦醇临床转化疗效的进一步研究将带来更多见解，而其他一些灰色地带，如白藜芦醇的最佳辐射防护剂量，仍需进一步研究。总体而言，白藜芦醇在保护健康组织的同时，在癌症治疗中是一把潜在的双刃剑。
