Haskins Laboratories, 300 George St., Suite 900, New Haven, CT, 06511, USA.
Section on Functional Imaging Methods, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Pediatr Radiol. 2021 Apr;51(4):628-639. doi: 10.1007/s00247-020-04875-y. Epub 2020 Nov 19.
Spatial normalization plays an essential role in multi-subject MRI and functional MRI (fMRI) experiments by facilitating a common space in which group analyses are performed. Although many prominent adult templates are available, their use for pediatric data is problematic. Generalized templates for pediatric populations are limited or constructed using older methods that result in less ideal normalization.
The Haskins pediatric templates and atlases aim to provide superior registration and more precise accuracy in labeling of anatomical and functional regions essential for all fMRI studies involving pediatric populations.
The Haskins pediatric templates and atlases were generated with nonlinear methods using structural MRI from 72 children (age range 7-14 years, median 10 years), allowing for a detailed template with corresponding parcellations of labeled atlas regions. The accuracy of these templates and atlases was assessed using multiple metrics of deformation distance and overlap.
When comparing the deformation distances from normalizing pediatric data between this template and both the adult templates and other pediatric templates, we found significantly less deformation distance for the Haskins pediatric template (P<0.0001). Further, the correct atlas classification was higher using the Haskins pediatric template in 74% of regions (P<0.0001).
The Haskins pediatric template results in more accurate correspondence across subjects because of lower deformation distances. This correspondence also provides better accuracy in atlas locations to benefit structural and functional imaging analyses of pediatric populations.
空间标准化在多主体 MRI 和功能磁共振成像 (fMRI) 实验中起着至关重要的作用，通过提供一个共同的空间来进行组分析。尽管有许多著名的成人模板可用，但它们在儿科数据中的应用存在问题。针对儿科人群的通用模板有限，或者使用较旧的方法构建，导致归一化效果不理想。
哈斯金斯儿科模板和图谱旨在提供卓越的配准，并在涉及儿科人群的所有 fMRI 研究中对解剖和功能区域进行更精确的标注，这些区域至关重要。
使用来自 72 名儿童（年龄范围 7-14 岁，中位数 10 岁）的结构 MRI，采用非线性方法生成哈斯金斯儿科模板和图谱，允许进行详细的模板制作，并对标记的图谱区域进行相应的分区。使用变形距离和重叠的多个度量标准来评估这些模板和图谱的准确性。
当比较使用该模板和成人模板以及其他儿科模板对儿科数据进行归一化时的变形距离，我们发现哈斯金斯儿科模板的变形距离明显更小（P<0.0001）。此外，在 74%的区域中，使用哈斯金斯儿科模板的正确图谱分类更高（P<0.0001）。
由于变形距离较小，哈斯金斯儿科模板可实现更准确的受试者间对应。这种对应关系还为儿科人群的结构和功能成像分析提供了更准确的图谱位置，从而带来益处。
