Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Québec, Canada; Intersectorial Centre for Endocrine Disruptors Analysis, Institut National de La Recherche Scientifique (INRS), Québec, Canada; ARThrite Research Center, Laval University, Québec, Canada.
Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Québec, Canada.
Environ Res. 2021 Apr;195:110485. doi: 10.1016/j.envres.2020.110485. Epub 2020 Nov 16.
Bisphenols are endocrine-disrupting chemicals found in a broad range of products that can modulate hormonal signalling pathways and various other biological functions. These compounds can bind steroid receptors, e.g. estrogen and androgen receptors, expressed by numerous cells and tissues, including the prostate and the bladder, with the potential to alter their homeostasis and normal physiological functions. In the past years, exposure to bisphenols was linked to cancer progression and metastasis. As such, recent pieces of evidence suggest that endocrine-disrupting chemicals can lead to the development of prostate cancer. Moreover, bisphenols are found in the urine of the wide majority of the population. They could potentially affect the bladder's normal physiology and cancer development, even if the bladder is not recognized as a hormone-sensitive tissue. This review will focus on prostate and bladder malignancies, two urological cancers that share standard carcinogenic processes. The description of the underlying mechanisms involved in cell toxicity, and the possible roles of bisphenols in the development of prostate and bladder cancer, could help establish the putative roles of bisphenols on public health.
双酚类物质是一种内分泌干扰化学物质，存在于广泛的产品中，可调节激素信号通路和各种其他生物学功能。这些化合物可以与许多细胞和组织（包括前列腺和膀胱）表达的甾体受体（如雌激素和雄激素受体）结合，从而改变它们的内稳态和正常生理功能。在过去的几年中，接触双酚类物质与癌症的进展和转移有关。因此，最近的一些证据表明，内分泌干扰化学物质可导致前列腺癌的发生。此外，双酚类物质存在于绝大多数人群的尿液中。即使膀胱不被认为是一种激素敏感组织，它们也可能影响膀胱的正常生理和癌症发展。本综述将重点讨论前列腺和膀胱癌这两种具有共同致癌过程的泌尿系统癌症。描述细胞毒性涉及的潜在机制，以及双酚类物质在前列腺癌和膀胱癌发展中的可能作用，有助于确定双酚类物质对公众健康的潜在作用。
