Pellerin Ève, Pellerin Félix-Antoine, Chabaud Stéphane, Pouliot Frédéric, Bolduc Stéphane, Pelletier Martin
Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Quebec, QC G1J 1Z4, Canada.
Oncology Division, CHU de Québec-Université Laval Research Center, Quebec, QC G1R 2J6, Canada.
Cancers (Basel). 2022 Aug 19;14(16):4011. doi: 10.3390/cancers14164011.
Bisphenol A (BPA) and bisphenol S (BPS) are used in the production of plastics. These endocrine disruptors can be released into the environment and food, resulting in the continuous exposure of humans to bisphenols (BPs). The bladder urothelium is chronically exposed to BPA and BPS due to their presence in human urine samples. BPA and BPS exposure has been linked to cancer progression, especially for hormone-dependent cancers. However, the bladder is not recognized as a hormone-dependent tissue. Still, the presence of hormone receptors on the urothelium and their role in bladder cancer initiation and progression suggest that BPs could impact bladder cancer development. The effects of chronic exposure to BPA and BPS for 72 h on the bioenergetics (glycolysis and mitochondrial respiration), proliferation and migration of normal urothelial cells and non-invasive and invasive bladder cancer cells were evaluated. The results demonstrate that chronic exposure to BPs decreased urothelial cells' energy metabolism and properties while increasing them for bladder cancer cells. These findings suggest that exposure to BPA and BPS could promote bladder cancer development with a potential clinical impact on bladder cancer progression. Further studies using 3D models would help to understand the clinical consequences of this exposure.
双酚A（BPA）和双酚S（BPS）用于塑料生产。这些内分泌干扰物可释放到环境和食物中，导致人类持续接触双酚类物质（BPs）。由于人类尿液样本中存在BPA和BPS，膀胱尿路上皮会长期暴露于它们。BPA和BPS暴露与癌症进展有关，尤其是激素依赖性癌症。然而，膀胱并不被认为是激素依赖性组织。尽管如此，尿路上皮上激素受体的存在及其在膀胱癌发生和进展中的作用表明，双酚类物质可能会影响膀胱癌的发展。评估了正常尿路上皮细胞以及非侵袭性和侵袭性膀胱癌细胞在72小时内长期暴露于BPA和BPS对生物能量学（糖酵解和线粒体呼吸）、增殖和迁移的影响。结果表明，长期暴露于双酚类物质会降低尿路上皮细胞的能量代谢和特性，而对膀胱癌细胞则会增加这些方面。这些发现表明，暴露于BPA和BPS可能会促进膀胱癌的发展，对膀胱癌进展具有潜在的临床影响。使用三维模型进行的进一步研究将有助于了解这种暴露的临床后果。
