Department of Clinical Nutrition and Department of Health Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing 100730, China.
Department of Clinical Nutrition, Hebei General Hospital, Shijiazhuang 050051, China.
Appl Physiol Nutr Metab. 2021 May;46(5):494-500. doi: 10.1139/apnm-2020-0643. Epub 2020 Nov 20.
This study aimed to determine the impact of nutrition supplementation (whey protein, fish oil, vitamin D) and physical exercise (resistance and aerobic exercise) on muscle mass, muscle strength and fat mass among sarcopenic elderly. Participants ( = 241) with sarcopenia (aged ≥ 60 y) enrolled from 2 centers were randomized into groups undergoing nutrition supplementation (Nutr), physical exercise (Ex), nutrition combined with exercise (Nutr+Ex), or routine consultation for 12 weeks. Muscle-related indicators, grip strength as well as fat-related indicators were compared pre- and post-intervention. The per-protocol analysis showed that all indicators were significantly different between groups ( < 0.001). Further pairwise comparisons showed that compared with controls, appendicular muscle mass and grip strength were significantly higher in Nutr ( < 0.001, 95% CI: 0.578, 1.475; < 0.001, 95% CI: 3.614∼9.118), Ex ( = 0.010, 95% CI: 0.157, 1.153; < 0.001, 95% CI: 2.904, 8.732), and Nutr+Ex ( < 0.001, 95% CI: 0.564, 1.471; < 0.001, 95% CI: 3.441, 8.907) groups, while fat mass was significantly lower in the Nutr ( < 0.001, 95% CI: -4.676, -2.358) and Nutr+Ex ( < 0.001, 95% CI: -4.717,-1.790) groups. When compared with Ex, fat mass decreased significantly in the Nutr ( = 0.001, 95% CI: -4.856,-1.359) and Nutr+Ex ( = 0.005, 95% CI: -4.810, -0.878) groups. The findings indicate that nutrition supplementation and physical exercise could improve muscle mass, strength and fat mass among sarcopenic elderly. Nutrition supplementation might be better at decreasing fat mass in this population. ClinicalTrials.gov registration no.: NCT02873676. Nutrition supplementation improved muscle mass, strength and fat mass among sarcopenic elderly. Aerobic and resistance exercise improved muscle mass and strength in sarcopenic elderly. Combined nutrition supplementation and physical exercise improved muscle mass, strength and fat mass among sarcopenic elderly.
本研究旨在探讨营养补充（乳清蛋白、鱼油、维生素 D）和体育锻炼（抗阻运动和有氧运动）对老年肌少症患者肌肉量、肌肉力量和体脂肪量的影响。共有来自 2 个中心的 241 名肌少症（年龄≥60 岁）患者参与了这项研究，他们被随机分为营养补充组（Nutr）、体育锻炼组（Ex）、营养联合运动组（Nutr+Ex）或常规咨询组，干预时间为 12 周。在干预前后比较了肌肉相关指标、握力和体脂相关指标。意向性治疗分析显示，各组间所有指标均有显著差异（<0.001）。进一步的两两比较显示，与对照组相比，Nutr 组（<0.001，95%CI：0.578，1.475；<0.001，95%CI：3.614∼9.118）、Ex 组（=0.010，95%CI：0.157，1.153；<0.001，95%CI：2.904，8.732）和 Nutr+Ex 组（<0.001，95%CI：0.564，1.471；<0.001，95%CI：3.441，8.907）的四肢肌肉量和握力显著增加，而 Nutr 组（<0.001，95%CI：-4.676，-2.358）和 Nutr+Ex 组（<0.001，95%CI：-4.717，-1.790）的体脂肪量显著降低。与 Ex 组相比，Nutr 组（=0.001，95%CI：-4.856，-1.359）和 Nutr+Ex 组（=0.005，95%CI：-4.810，-0.878）的体脂肪量也有显著降低。这些结果表明，营养补充和体育锻炼可以改善老年肌少症患者的肌肉量、力量和体脂肪量。营养补充可能更有助于降低该人群的体脂肪量。临床试验注册号：NCT02873676。营养补充改善了老年肌少症患者的肌肉量、力量和体脂肪量。有氧运动和抗阻运动改善了老年肌少症患者的肌肉量和力量。营养补充联合体育锻炼改善了老年肌少症患者的肌肉量、力量和体脂肪量。
