Shao Yuze, Wang Kai, Jiang Zhenyuan, Yu Xiaowen, An Wenrong, Han Yue, Wang Zhonglin
Shandong University of Traditional Chinese Medicine.
Shandong Provincial Hospital Affiliated to Shandong First Medical University.
Medicine (Baltimore). 2020 Nov 20;99(47):e23199. doi: 10.1097/MD.0000000000023199.
Major depression disorder (MDD) is a severe health threat characterized by persistent depression, loss of interests, lack of initiative, and even suicidal tendencies. Traditional Chinese medicine (TCM) is well tolerated and effective in treating adult MDD. However, research on the evaluation of efficacy and acceptability of different TCM strategies for adult MDD is insufficient. Consequently, it is high time to evaluate the efficacy of TCM strategies for adult MDD. Meanwhile, the acceptability of different TCM strategies is worth exploring.
Comprehensively and systematically retrieve the literature in PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure Database (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and Chinese BioMedical Literature Database (CBM). The literature search will focus on randomized controlled trials (RCTs) with TCM in adult MDD. Two reviewers will search the literature and extract relevant data back-to-back. Once mismatched outcomes appear, arbitration will be conducted by a third reviewer. Based on the Bayesian framework, data analysis is carried out with STATA and WinBUGS software. Heterogeneity, transitivity, consistency test, bias risk assessment, subgroup and sensitivity analysis, evidence quality evaluation will be performed accordingly.
The efficacy and acceptability of different TCM strategies for adults with MDD will be compared and sorted.
The study will facilitate the treatment options of adults MDD according to the supporting evidence.
INPLASY2020100028.
重度抑郁症（MDD）是一种严重的健康威胁，其特征为持续抑郁、兴趣丧失、缺乏主动性，甚至有自杀倾向。中医在治疗成人MDD方面耐受性良好且疗效显著。然而，关于不同中医策略对成人MDD疗效和可接受性评估的研究并不充分。因此，是时候评估中医策略对成人MDD的疗效了。同时，不同中医策略的可接受性也值得探讨。
全面系统地检索PubMed、Cochrane图书馆、科学引文索引（Web of Science）、Embase、中国知网数据库（CNKI）、万方数据库、维普中文科技期刊数据库（VIP）和中国生物医学文献数据库（CBM）中的文献。文献检索将聚焦于中医治疗成人MDD的随机对照试验（RCT）。两名评审员将背对背检索文献并提取相关数据。一旦出现结果不匹配的情况，将由第三名评审员进行仲裁。基于贝叶斯框架，使用STATA和WinBUGS软件进行数据分析。相应地进行异质性、可传递性、一致性检验、偏倚风险评估、亚组和敏感性分析、证据质量评估。
将比较并梳理不同中医策略对成人MDD的疗效和可接受性。
该研究将根据支持证据为成人MDD的治疗选择提供便利。
INPLASY2020100028。
