Naessens A, Foulon W, Cammu H, Goossens A, Lauwers S
Department of Microbiology, Akademisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
Acta Obstet Gynecol Scand. 1987;66(6):513-6. doi: 10.3109/00016348709015726.
The role of U. urealyticum in spontaneous and recurrent spontaneous abortion was studied in 633 women. Cervical colonization with U. urealyticum was found in 42.6% of 310 normal pregnant women, in 41.6% of 84 patients who underwent induced abortion, in 41.5% of 41 normal fertile patients, in 53.3% of 122 patients with spontaneous abortion and in 64.5% of 76 patients with recurrent spontaneous abortion. The cervical isolation rate was significantly higher in patients with spontaneous abortion (p less than 0.05) and recurrent spontaneous abortion (p less than 0.005) than in normal pregnant women. Endometrial colonization was more frequent in patients with recurrent spontaneous abortion (27.6%) than in normal fertile women (9.7%) (p less than 0.05). Moreover, in 6 patients with intact membranes and uncontrollable preterm labor resulting in fetal loss (all between the 20th and 28th week of gestation) U. urealyticum was isolated in 5 of them from the cervix, in 4 patients from the placenta and in 2 out of 4 from the amniotic fluid. Histological examination of the placenta showed signs of chorioamnionitis in 5 patients. From this study we conclude that although U. urealyticum is a common inhabitant of the lower genital tract, it may play a role in the etiology of spontaneous abortion and uncontrollable preterm labor.
对633名女性研究了解脲脲原体在自然流产和复发性自然流产中的作用。在310名正常孕妇中，42.6%的人宫颈有解脲脲原体定植；在84名接受人工流产的患者中，41.6%有定植；在41名正常可育患者中，41.5%有定植；在122名自然流产患者中，53.3%有定植；在76名复发性自然流产患者中，64.5%有定植。自然流产患者（p<0.05）和复发性自然流产患者（p<0.005）的宫颈分离率显著高于正常孕妇。复发性自然流产患者（27.6%）的子宫内膜定植比正常可育女性（9.7%）更常见（p<0.05）。此外，在6名胎膜完整但不可控制的早产导致胎儿丢失的患者（均在妊娠第20至28周之间）中，5人宫颈分离出解脲脲原体，4人胎盘分离出解脲脲原体，4人中2人羊水分离出解脲脲原体。5名患者的胎盘组织学检查显示有绒毛膜羊膜炎迹象。从这项研究我们得出结论，虽然解脲脲原体是下生殖道的常见寄居菌，但它可能在自然流产和不可控制的早产病因中起作用。
