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新加坡 COVID-19 患者的人口结构变化,从老龄化、高危人群转变为年轻移民工人,他们患重病的风险降低。

Demographic shift in COVID-19 patients in Singapore from an aged, at-risk population to young migrant workers with reduced risk of severe disease.

机构信息

Department of Medicine, National University Health System, Singapore.

Department of Cardiology, National University Heart Centre Singapore, Singapore.

出版信息

Int J Infect Dis. 2021 Feb;103:329-335. doi: 10.1016/j.ijid.2020.11.157. Epub 2020 Nov 19.

Abstract

OBJECTIVES

The vast majority of COVID-19 cases in Singapore have occurred amongst migrant workers. This paper examined trends in the hospitalised cases and tested the assumption that the low severity of disease was related to the relatively young affected population.

METHODS

All patients with PCR-positive SARS-CoV-2 admitted from February to April 2020 were divided into: (i) imported cases, (ii) locally-transmitted cases outside migrant worker dormitories and (iii) migrant worker dormitory cases. They were examined for underlying comorbidities, clinical progress and outcomes.

RESULTS

Imported cases (n = 29) peaked in mid-March 2020, followed by local cases (n = 100) in mid-April 2020; migrant worker cases (n = 425) continued to increase in late April 2020. Migrant worker cases were younger, had few medical comorbidities and less severe disease. As the migrant worker cases increased, the proportion of patients with pneumonia decreased, whilst patients presenting earlier in their illness and asymptomatic disease became more common.

CONCLUSION

Singapore experienced a substantial shift in the population at risk of severe COVID-19. Successful control in the community protected an aging population. Large migrant worker dormitory outbreaks occurred, but the disease incurred was less severe, resulting in Singapore having one of the lowest case fatality rates in the world.

摘要

目的

新加坡绝大多数 COVID-19 病例发生在移民工人中。本文研究了住院病例的趋势,并检验了疾病严重程度较低与受影响人群相对年轻有关的假设。

方法

将 2020 年 2 月至 4 月期间因 PCR 阳性 SARS-CoV-2 入院的所有患者分为:(i)输入病例,(ii)移民工人宿舍外的本地传播病例,和 (iii)移民工人宿舍病例。检查了他们的潜在合并症、临床进展和结果。

结果

输入病例(n=29)于 2020 年 3 月中旬达到高峰,随后是本地病例(n=100)于 2020 年 4 月中旬;移民工人病例(n=425)在 2020 年 4 月下旬继续增加。移民工人病例年龄较小,合并症较少,疾病较轻。随着移民工人病例的增加,肺炎患者的比例下降,而在疾病早期出现和无症状疾病的患者变得更为常见。

结论

新加坡经历了 COVID-19 高危人群的重大转变。社区内的成功控制保护了老年人口。大型移民工人宿舍爆发,但疾病较轻,导致新加坡成为全球病死率最低的国家之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81fa/7674985/d44f6e7c9efe/gr1_lrg.jpg

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